biostudies-literatureEum DYDongnam Institute of Radiological & Medical SciencesMinistry of Science and ICT, South Koreae0296989https://www.ebi.ac.uk/biostudies/studies/S-EPMC11020960biostudies-literatureUnknown19(4)Natural anmindenol A isolated from the marine-derived bacteria Streptomyces sp. caused potent inhibition of inducible nitric oxide synthase without any significant cytotoxicity. This compound consists of a structurally unique 3,10-dialkylbenzofulvene skeleton. We previously synthesized and screened the novel derivatives of anmindenol A and identified AM-18002, an anmindenol A derivative, as a promising anticancer agent. The combination of AM-18002 and ionizing radiation (IR) improved anticancer effects, which were exerted by promoting apoptosis and inhibiting the proliferation of FM3A mouse breast cancer cells. AM-18002 increased the production of reactive oxygen species (ROS) and was more effective in inducing DNA damage. AM-18002 treatment was found to inhibit the expansion of myeloid-dePloS oneAM-18002, a derivative of natural anmindenol A, enhances radiosensitivity in mouse breast cancer cells.PMC1102096050591-2023RS-2023-00218778Shim JWYun HChoi YJEum DYKim JHeo KJeong MPark SYJin YJo JLee SRPark SJfalseAM-18002, a derivative of natural anmindenol A, enhances radiosensitivity in mouse breast cancer cells.Natural anmindenol A isolated from the marine-derived bacteria Streptomyces sp. caused potent inhibition of inducible nitric oxide synthase without any significant cytotoxicity. This compound consists of a structurally unique 3,10-dialkylbenzofulvene skeleton. We previously synthesized and screened the novel derivatives of anmindenol A and identified AM-18002, an anmindenol A derivative, as a promising anticancer agent. The combination of AM-18002 and ionizing radiation (IR) improved anticancer effects, which were exerted by promoting apoptosis and inhibiting the proliferation of FM3A mouse breast cancer cells. AM-18002 increased the production of reactive oxygen species (ROS) and was more effective in inducing DNA damage. AM-18002 treatment was found to inhibit the expansion of myeloid-de2024-01-01T00:00:00Z20242026-06-02T06:03:35.969Z2026-04-15T03:09:59.893ZS-EPMC110209603862590110.1371/journal.pone.0296989