biostudies-literatureBinks SNMPetre FoundationEpilepsy Research UKMedical Research CouncilNIHR Oxford Biomedical Research CentreNational Institute for Health Research (NIHR)National Health and Medical Research CouncilUniversity of SydneyNational Institute for Health and Care ResearchBritish Medical AssociationWellcome TrustRoyal Australasian College of PhysiciansUS-UK Fulbright Commission1053-1058https://www.ebi.ac.uk/biostudies/studies/S-EPMC11021603biostudies-literatureUnknown11(4)Patient-reported quality-of-life (QoL) and carer impacts are not reported after leucine-rich glioma-inactivated 1-antibody encephalitis (LGI1-Ab-E). From 60 patients, 85% (51 out of 60) showed one abnormal score across QoL assessments and 11 multimodal validated questionnaires. Compared to the premorbid state, QoL significantly deteriorated (p < 0.001) and, at a median of 41 months, fatigue was its most important predictor (p = 0.025). In total, 51% (26 out of 51) of carers reported significant burden. An abbreviated five-item battery explained most variance in QoL. Wide-ranging impacts post-LGI1-Ab-E include decreased QoL and high caregiver strain. We identify a rapid method to capture QoL in routine clinic or clinical trial settings.Annals of clinical and translational neurologyFatigue predicts quality of life after leucine-rich glioma-inactivated 1-antibody encephalitis.PMC11021603MR/V007173/1CL-2022-13-007Margaret Temple 2017206330/Z/17/ZP1201MR/X022013/1Vera Down grant 2013104079/Z/14/ZGNT2008339Michael SNissen MSJacob SOkai DBinks SNMHandel AEIrani SRCoebergh JBlaabjerg MMaddison PRamanathan SLeite MIEaston AHusain MVeldsman MfalseFatigue predicts quality of life after leucine-rich glioma-inactivated 1-antibody encephalitis.Patient-reported quality-of-life (QoL) and carer impacts are not reported after leucine-rich glioma-inactivated 1-antibody encephalitis (LGI1-Ab-E). From 60 patients, 85% (51 out of 60) showed one abnormal score across QoL assessments and 11 multimodal validated questionnaires. Compared to the premorbid state, QoL significantly deteriorated (p < 0.001) and, at a median of 41 months, fatigue was its most important predictor (p = 0.025). In total, 51% (26 out of 51) of carers reported significant burden. An abbreviated five-item battery explained most variance in QoL. Wide-ranging impacts post-LGI1-Ab-E include decreased QoL and high caregiver strain. We identify a rapid method to capture QoL in routine clinic or clinical trial settings.2024-01-01T00:00:00Z2024 Apr2025-04-04T12:58:21.216Z2025-04-04T12:58:21.216ZS-EPMC110216033830348610.1002/acn3.52006