{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(4)"],"submitter":["Stammler R"],"pubmed_abstract":["<h4>Objective</h4>The stroke risk for persons living with human immunodeficiency virus (PLHIVs) doubled compared to uninfected individuals. Stroke-unit (SU)-access, acute reperfusion therapy-use and outcome data on PLHIVs admitted for acute ischemic stroke (AIS) are scarce.<h4>Methods</h4>AIS patients admitted (01 January 2017 to 31 January 2021) to 10 representative Paris-area SUs were screened retrospectively from the National Hospitalization Database. PLHIVs were compared to age-, initial NIHSS- and sex-matched HIV-uninfected controls (HUCs). Outcome was the 90-day modified Rankin Scale score.<h4>Results</h4>Among 126 PLHIVs with confirmed first-ever AIS, ~80% were admitted outside the thrombolysis-administration window. Despite antiretrovirals, uncontrolled plasma HIV loads exceeded 50"],"journal":["Annals of clinical and translational neurology"],"pagination":["916-925"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11021677"],"repository":["biostudies-literature"],"pubmed_title":["First-ever acute ischemic strokes in HIV-infected persons: A case-control study from stroke units."],"pmcid":["PMC11021677"],"pubmed_authors":["Stammler R","Raynouard I","Guillaume J","Obadia M","Lapergue B","Moulignier A","Hosseini H","Leger A","Smadja D","Mazighi M","Meseguer E","Denier C","Lamy C","De Broucker T"],"additional_accession":[]},"is_claimable":false,"name":"First-ever acute ischemic strokes in HIV-infected persons: A case-control study from stroke units.","description":"<h4>Objective</h4>The stroke risk for persons living with human immunodeficiency virus (PLHIVs) doubled compared to uninfected individuals. Stroke-unit (SU)-access, acute reperfusion therapy-use and outcome data on PLHIVs admitted for acute ischemic stroke (AIS) are scarce.<h4>Methods</h4>AIS patients admitted (01 January 2017 to 31 January 2021) to 10 representative Paris-area SUs were screened retrospectively from the National Hospitalization Database. PLHIVs were compared to age-, initial NIHSS- and sex-matched HIV-uninfected controls (HUCs). Outcome was the 90-day modified Rankin Scale score.<h4>Results</h4>Among 126 PLHIVs with confirmed first-ever AIS, ~80% were admitted outside the thrombolysis-administration window. Despite antiretrovirals, uncontrolled plasma HIV loads exceeded 50","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-04T12:58:54.495Z","creation":"2025-04-04T12:58:54.495Z"},"accession":"S-EPMC11021677","cross_references":{"pubmed":["38287505"],"doi":["10.1002/acn3.52008"]}}