biostudies-literatureUnknown11(4)Stammler R<h4>Objective</h4>The stroke risk for persons living with human immunodeficiency virus (PLHIVs) doubled compared to uninfected individuals. Stroke-unit (SU)-access, acute reperfusion therapy-use and outcome data on PLHIVs admitted for acute ischemic stroke (AIS) are scarce.<h4>Methods</h4>AIS patients admitted (01 January 2017 to 31 January 2021) to 10 representative Paris-area SUs were screened retrospectively from the National Hospitalization Database. PLHIVs were compared to age-, initial NIHSS- and sex-matched HIV-uninfected controls (HUCs). Outcome was the 90-day modified Rankin Scale score.<h4>Results</h4>Among 126 PLHIVs with confirmed first-ever AIS, ~80% were admitted outside the thrombolysis-administration window. Despite antiretrovirals, uncontrolled plasma HIV loads exceeded 50Annals of clinical and translational neurology916-925https://www.ebi.ac.uk/biostudies/studies/S-EPMC11021677biostudies-literatureFirst-ever acute ischemic strokes in HIV-infected persons: A case-control study from stroke units.PMC11021677Stammler RRaynouard IGuillaume JObadia MLapergue BMoulignier AHosseini HLeger ASmadja DMazighi MMeseguer EDenier CLamy CDe Broucker TfalseFirst-ever acute ischemic strokes in HIV-infected persons: A case-control study from stroke units.<h4>Objective</h4>The stroke risk for persons living with human immunodeficiency virus (PLHIVs) doubled compared to uninfected individuals. Stroke-unit (SU)-access, acute reperfusion therapy-use and outcome data on PLHIVs admitted for acute ischemic stroke (AIS) are scarce.<h4>Methods</h4>AIS patients admitted (01 January 2017 to 31 January 2021) to 10 representative Paris-area SUs were screened retrospectively from the National Hospitalization Database. PLHIVs were compared to age-, initial NIHSS- and sex-matched HIV-uninfected controls (HUCs). Outcome was the 90-day modified Rankin Scale score.<h4>Results</h4>Among 126 PLHIVs with confirmed first-ever AIS, ~80% were admitted outside the thrombolysis-administration window. Despite antiretrovirals, uncontrolled plasma HIV loads exceeded 502024-01-01T00:00:00Z2024 Apr2025-04-04T12:58:54.495Z2025-04-04T12:58:54.495ZS-EPMC110216773828750510.1002/acn3.52008