biostudies-literatureKyler KEEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesNIDDK NIH HHSe13782https://www.ebi.ac.uk/biostudies/studies/S-EPMC11022290biostudies-literatureUnknown17(4)In this brief report, we provide an analysis of the influence of a novel CYP2C haplotype (CYP2C:TG) on proton pump inhibitor (PPI) pharmacokinetics (PK) in children. The CYP2C:TG haplotype has been proposed to be associated with increased CYP2C19 activity. We sought to determine if this CYP2C:TG haplotype resulted in similar alterations in metabolism for proton pump inhibitors, which are primarily metabolized by CYP2C19. In a cohort of 41 children aged 6-21 participating in a PPI pharmacokinetic study, effects of the CYP2C:TG allele were assessed by fitting two linear regression models for each of the six PK outcomes assessed, the second of which accounted for the presence of the CYP2C:TG allele. The difference in R² values between the two models was computed to quantify the varClinical and translational scienceInfluence of novel CYP2C-haplotype on proton pump inhibitor pharmacokinetics in children.PMC11022290K23 DK115827T32 HD069038Leeder JSStaggs VSPearce REKyler KEAbdel-Rahman SGaedigk AToren PShakhnovich VfalseInfluence of novel CYP2C-haplotype on proton pump inhibitor pharmacokinetics in children.In this brief report, we provide an analysis of the influence of a novel CYP2C haplotype (CYP2C:TG) on proton pump inhibitor (PPI) pharmacokinetics (PK) in children. The CYP2C:TG haplotype has been proposed to be associated with increased CYP2C19 activity. We sought to determine if this CYP2C:TG haplotype resulted in similar alterations in metabolism for proton pump inhibitors, which are primarily metabolized by CYP2C19. In a cohort of 41 children aged 6-21 participating in a PPI pharmacokinetic study, effects of the CYP2C:TG allele were assessed by fitting two linear regression models for each of the six PK outcomes assessed, the second of which accounted for the presence of the CYP2C:TG allele. The difference in R² values between the two models was computed to quantify the var2024-01-01T00:00:00Z2024 Apr2026-06-02T08:19:46.682Z2026-05-26T03:06:48.32ZS-EPMC110222903862950210.1111/cts.13782