{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["628(8008)"],"submitter":["Lu YZ"],"pubmed_abstract":["The immune system has a critical role in orchestrating tissue healing. As a result, regenerative strategies that control immune components have proved effective<sup>1,2</sup>. This is particularly relevant when immune dysregulation that results from conditions such as diabetes or advanced age impairs tissue healing following injury<sup>2,3</sup>. Nociceptive sensory neurons have a crucial role as immunoregulators and exert both protective and harmful effects depending on the context<sup>4-12</sup>. However, how neuro-immune interactions affect tissue repair and regeneration following acute injury is unclear. Here we show that ablation of the Na<sub>V</sub>1.8 nociceptor impairs skin wound repair and muscle regeneration after acute tissue injury. Nociceptor endings grow into injured skin an"],"journal":["Nature"],"pagination":["604-611"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11023938"],"repository":["biostudies-literature"],"pubmed_title":["CGRP sensory neurons promote tissue healing via neutrophils and macrophages."],"pmcid":["PMC11023938"],"pubmed_authors":["Nayer B","Yuan E","Alshoubaki YK","Maruyama K","Martino MM","Akira S","Lu YZ","Singh SK","Park AJ"],"additional_accession":[]},"is_claimable":false,"name":"CGRP sensory neurons promote tissue healing via neutrophils and macrophages.","description":"The immune system has a critical role in orchestrating tissue healing. As a result, regenerative strategies that control immune components have proved effective<sup>1,2</sup>. This is particularly relevant when immune dysregulation that results from conditions such as diabetes or advanced age impairs tissue healing following injury<sup>2,3</sup>. Nociceptive sensory neurons have a crucial role as immunoregulators and exert both protective and harmful effects depending on the context<sup>4-12</sup>. However, how neuro-immune interactions affect tissue repair and regeneration following acute injury is unclear. Here we show that ablation of the Na<sub>V</sub>1.8 nociceptor impairs skin wound repair and muscle regeneration after acute tissue injury. Nociceptor endings grow into injured skin an","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-03-12T22:43:29.255Z","creation":"2025-08-12T03:04:57.442Z"},"accession":"S-EPMC11023938","cross_references":{"pubmed":["38538784"],"doi":["10.1038/s41586-024-07237-y"]}}