biostudies-literatureUnknown628(8008)Lu YZThe immune system has a critical role in orchestrating tissue healing. As a result, regenerative strategies that control immune components have proved effective^1,2. This is particularly relevant when immune dysregulation that results from conditions such as diabetes or advanced age impairs tissue healing following injury^2,3. Nociceptive sensory neurons have a crucial role as immunoregulators and exert both protective and harmful effects depending on the context^4-12. However, how neuro-immune interactions affect tissue repair and regeneration following acute injury is unclear. Here we show that ablation of the Na_V1.8 nociceptor impairs skin wound repair and muscle regeneration after acute tissue injury. Nociceptor endings grow into injured skin anNature604-611https://www.ebi.ac.uk/biostudies/studies/S-EPMC11023938biostudies-literatureCGRP sensory neurons promote tissue healing via neutrophils and macrophages.PMC11023938Nayer BYuan EAlshoubaki YKMaruyama KMartino MMAkira SLu YZSingh SKPark AJfalseCGRP sensory neurons promote tissue healing via neutrophils and macrophages.The immune system has a critical role in orchestrating tissue healing. As a result, regenerative strategies that control immune components have proved effective^1,2. This is particularly relevant when immune dysregulation that results from conditions such as diabetes or advanced age impairs tissue healing following injury^2,3. Nociceptive sensory neurons have a crucial role as immunoregulators and exert both protective and harmful effects depending on the context^4-12. However, how neuro-immune interactions affect tissue repair and regeneration following acute injury is unclear. Here we show that ablation of the Na_V1.8 nociceptor impairs skin wound repair and muscle regeneration after acute tissue injury. Nociceptor endings grow into injured skin an2024-01-01T00:00:00Z2024 Apr2026-03-12T22:43:29.255Z2025-08-12T03:04:57.442ZS-EPMC110239383853878410.1038/s41586-024-07237-y