{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["72"],"submitter":["Zheng L"],"pubmed_abstract":["Background
Endovascular therapy (EVT) was demonstrated effective in acute large vessel occlusion (LVO) with large infarction. Revealing subgroups of patients who would or would not benefit from EVT will further inform patient selection for EVT.Methods
This post-hoc analysis of the ANGEL-ASPECT trial, a randomised controlled trial of 456 adult patients with acute anterior-circulation LVO and large infarction, defined by ASPECTS 3-5 or infarct core volume 70-100 mL, enrolled from 46 centres across China, between October 2, 2020 and May 18, 2022. Patients were randomly assigned (1:1) to receiving EVT and medical management or medical management alone. One patient withdrew consent, 455 patients were included in this post-hoc analysis and categorised into 4 subgroups by lower or"],"journal":["EClinicalMedicine"],"pagination":["102595"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11024914"],"repository":["biostudies-literature"],"pubmed_title":["Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial."],"pmcid":["PMC11024914"],"pubmed_authors":["Zhang K","Guo Z","Zhang J","Shi Q","Deng J","Zhang L","ANGEL-ASPECT Investigators","Jin A","Nan G","Guo C","An R","Xu N","Zheng S","Pereira VM","Yuan G","He Y","Hu M","Jiang C","Geng X","Ren Z","Wei Y","Yu H","Zhao X","Wei M","Qi Z","Liu Chair J","Liao G","Zhou F","Yu Z","Leung TW","Zhao J","Tang Y","Jing Chair J","Cui L","Ling W","Zhou Z","Dai L","Yu C","Han H","Xuan J","Kong W","Dong Y","Lu X","Wang E","Wang G","Dong Q","Wang J","Wang M","Wang N","Wen M","Liebeskind DS","Sun D","Chen W","Gui L","Wen C","Chen Y","Wang W","Chen X","Wang Y","Wu W","Wang Z","Wu Y","Yang H","Yang J","Li J","Chen K","Li C","Li D","Chen F","Li K","Yao X","Sun Y","Yang Z","Li S","Li T","Huo X","Leng X","Yao C","Gao Z","Yang Q","Liu J","Liu L","Liu S","Liu W","Liu X","Liu Y","Liu Z","Cai C","Zheng H","Zheng L","Xu A","Nguyen TN","Yi-Chou Wang A","Song W","Nie X","Pan Y","Song B","Ji F","Luo G","Song C","Ju D","Ji P","Ji X","Zhang Z","Luo J","Zhang Y","Yin C","Xiang X","Liu B","Duan W","Fang Chair K","Yan H","Miao Z","Cai X","Ma G"],"additional_accession":[]},"is_claimable":false,"name":"Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial.","description":"Background
Endovascular therapy (EVT) was demonstrated effective in acute large vessel occlusion (LVO) with large infarction. Revealing subgroups of patients who would or would not benefit from EVT will further inform patient selection for EVT.Methods
This post-hoc analysis of the ANGEL-ASPECT trial, a randomised controlled trial of 456 adult patients with acute anterior-circulation LVO and large infarction, defined by ASPECTS 3-5 or infarct core volume 70-100 mL, enrolled from 46 centres across China, between October 2, 2020 and May 18, 2022. Patients were randomly assigned (1:1) to receiving EVT and medical management or medical management alone. One patient withdrew consent, 455 patients were included in this post-hoc analysis and categorised into 4 subgroups by lower or","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-05-29T09:45:00.364Z","creation":"2025-07-27T03:11:10.179Z"},"accession":"S-EPMC11024914","cross_references":{"pubmed":["38638180"],"doi":["10.1016/j.eclinm.2024.102595"]}}