{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(3)"],"submitter":["Song H"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["Extinction selectivity determines the direction of macroevolution, especially during mass extinction; however, its driving mechanisms remain poorly understood. By investigating the physiological selectivity of marine animals during the Permian-Triassic mass extinction, we found that marine clades with lower O<sub>2</sub>-carrying capacity hemerythrin proteins and those relying on O<sub>2</sub> diffusion experienced significantly greater extinction intensity and body-size reduction than those with higher O<sub>2</sub>-carrying capacity hemoglobin or hemocyanin proteins. Our findings suggest that animals with high O<sub>2</sub>-carrying capacity obtained the necessary O<sub>2</sub> even under hypoxia and compensated for the increased energy requirements caused by ocean acidification, which enabled their survival during the Permian-Triassic mass extinction. Thus, high O<sub>2</sub>-carrying capacity may have been crucial for the transition from the Paleozoic to the Modern Evolutionary Fauna."],"journal":["Innovation (Cambridge (Mass.))"],"pagination":["100618"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11025005"],"repository":["biostudies-literature"],"pubmed_title":["Respiratory protein-driven selectivity during the Permian-Triassic mass extinction."],"pmcid":["PMC11025005"],"pubmed_authors":["Tian L","Dal Corso J","Chu D","Feng Y","Foster WJ","Wang F","Song H","Wu Y","Dai X"],"additional_accession":[]},"is_claimable":false,"name":"Respiratory protein-driven selectivity during the Permian-Triassic mass extinction.","description":"Extinction selectivity determines the direction of macroevolution, especially during mass extinction; however, its driving mechanisms remain poorly understood. By investigating the physiological selectivity of marine animals during the Permian-Triassic mass extinction, we found that marine clades with lower O<sub>2</sub>-carrying capacity hemerythrin proteins and those relying on O<sub>2</sub> diffusion experienced significantly greater extinction intensity and body-size reduction than those with higher O<sub>2</sub>-carrying capacity hemoglobin or hemocyanin proteins. Our findings suggest that animals with high O<sub>2</sub>-carrying capacity obtained the necessary O<sub>2</sub> even under hypoxia and compensated for the increased energy requirements caused by ocean acidification, which enabled their survival during the Permian-Triassic mass extinction. Thus, high O<sub>2</sub>-carrying capacity may have been crucial for the transition from the Paleozoic to the Modern Evolutionary Fauna.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T10:48:47.946Z","creation":"2026-04-08T11:37:57.369Z"},"accession":"S-EPMC11025005","cross_references":{"pubmed":["38638583"],"doi":["10.1016/j.xinn.2024.100618"]}}