{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(5)"],"submitter":["Li S"],"funding":["Beijing Municipal Science and Technology Commission"],"pubmed_abstract":["Most advanced colorectal cancer (CRC) patients cannot benefit from targeted therapy due to lack of actionable targets. By mining data from the DepMap, we identified <i>FAM126B</i> as a specific vulnerability in CRC cell lines exhibiting low <i>FAM126A</i> expression. Employing a combination of genetic perturbation and inducible protein degradation techniques, we demonstrate that FAM126A and FAM126B function in a redundant manner to facilitate the recruitment of PI4KIIIα to the plasma membrane for PI4P synthesis. Examination of data from TCGA and GTEx revealed that over 7% of CRC tumor samples exhibited loss of <i>FAM126A</i> expression, contrasting with uniform <i>FAM126A</i> expression in normal tissues. In both CRC cell lines and tumor samples, promoter hypermethylation correlated with t"],"journal":["iScience"],"pagination":["109646"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11025007"],"repository":["biostudies-literature"],"pubmed_title":["Frequent loss of <i>FAM126A</i> expression in colorectal cancer results in selective <i>FAM126B</i> dependency."],"pmcid":["PMC11025007"],"pubmed_authors":["Li S","Han T"],"additional_accession":[]},"is_claimable":false,"name":"Frequent loss of <i>FAM126A</i> expression in colorectal cancer results in selective <i>FAM126B</i> dependency.","description":"Most advanced colorectal cancer (CRC) patients cannot benefit from targeted therapy due to lack of actionable targets. By mining data from the DepMap, we identified <i>FAM126B</i> as a specific vulnerability in CRC cell lines exhibiting low <i>FAM126A</i> expression. Employing a combination of genetic perturbation and inducible protein degradation techniques, we demonstrate that FAM126A and FAM126B function in a redundant manner to facilitate the recruitment of PI4KIIIα to the plasma membrane for PI4P synthesis. Examination of data from TCGA and GTEx revealed that over 7% of CRC tumor samples exhibited loss of <i>FAM126A</i> expression, contrasting with uniform <i>FAM126A</i> expression in normal tissues. In both CRC cell lines and tumor samples, promoter hypermethylation correlated with t","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-05-29T09:45:02.024Z","creation":"2025-07-27T03:11:10.489Z"},"accession":"S-EPMC11025007","cross_references":{"pubmed":["38638566"],"doi":["10.1016/j.isci.2024.109646"]}}