{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["81(5)"],"submitter":["Townsend RR"],"pubmed_abstract":["<h4>Background</h4>The SPYRAL HTN-ON MED (Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension in the Absence of Antihypertensive Medications)trial showed significant office and nighttime systolic blood pressure (BP) reductions in patients with hypertension following renal denervation (RDN) compared with sham-control patients, despite similar 24-hour BP reductions. We compared antihypertensive medication and BP changes among prespecified subpopulations.<h4>Methods</h4>The multicenter, randomized, sham-controlled, blinded SPYRAL HTN-ON MED trial (n=337) evaluated BP changes after RDN compared with a sham procedure in patients with hypertension prescribed 1 to 3 antihypertensive drugs. Most p"],"journal":["Hypertension (Dallas, Tex. : 1979)"],"pagination":["1095-1105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11025607"],"repository":["biostudies-literature"],"pubmed_title":["Impact of Antihypertensive Medication Changes After Renal Denervation Among Different Patient Groups: SPYRAL HTN-ON MED."],"pmcid":["PMC11025607"],"pubmed_authors":["Steigerwalt S","Bertolet B","Brar S","Mahfoud F","Fahy M","Schmieder RE","Weber MA","Pocock S","Sharif F","Hettrick DA","Tsioufis K","Kandzari DE","Townsend RR","Fengler K","Bohm M","Walton A","David S","Kario K","Hopper I","Ferdinand KC"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Antihypertensive Medication Changes After Renal Denervation Among Different Patient Groups: SPYRAL HTN-ON MED.","description":"<h4>Background</h4>The SPYRAL HTN-ON MED (Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension in the Absence of Antihypertensive Medications)trial showed significant office and nighttime systolic blood pressure (BP) reductions in patients with hypertension following renal denervation (RDN) compared with sham-control patients, despite similar 24-hour BP reductions. We compared antihypertensive medication and BP changes among prespecified subpopulations.<h4>Methods</h4>The multicenter, randomized, sham-controlled, blinded SPYRAL HTN-ON MED trial (n=337) evaluated BP changes after RDN compared with a sham procedure in patients with hypertension prescribed 1 to 3 antihypertensive drugs. Most p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-05-29T09:46:12.274Z","creation":"2025-07-27T03:10:30.236Z"},"accession":"S-EPMC11025607","cross_references":{"pubmed":["38314554"],"doi":["10.1161/HYPERTENSIONAHA.123.22251"]}}