biostudies-literatureUnknownZeng XNIBIB NIH HHSNational Institutes of HealthNIH HHS<h4>Background</h4>Positron emission tomography (PET) has had a transformative impact on oncological and neurological applications. However, still much of PET's potential remains untapped with limitations primarily driven by low spatial resolution, which severely hampers accurate quantitative PET imaging via the partial volume effect (PVE).<h4>Purpose</h4>We present experimental results of a practical and cost-effective ultra-high resolution brain-dedicated PET scanner, using our depth-encoding Prism-PET detectors arranged along a compact and conformal gantry, showing substantial reduction in PVE and accurate radiotracer uptake quantification in small regions.<h4>Methods</h4>The decagon-shaped prototype scanner has a long diameter of 38.5 cm, a short diameter of 29.1 cm, and an axial fieldMedical physicshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC11025680biostudies-literatureA conformal TOF-DOI Prism-PET prototype scanner for high-resolution quantitative neuroimaging.PMC11025680R01EB030413R01 EB030413Franceschi DQi JPetersen EZhao Wde Leon MZeng XBoccia AChiang GCCao XTan WLaBella AGoldan AHWang ZBiegon AfalseA conformal TOF-DOI Prism-PET prototype scanner for high-resolution quantitative neuroimaging.<h4>Background</h4>Positron emission tomography (PET) has had a transformative impact on oncological and neurological applications. However, still much of PET's potential remains untapped with limitations primarily driven by low spatial resolution, which severely hampers accurate quantitative PET imaging via the partial volume effect (PVE).<h4>Purpose</h4>We present experimental results of a practical and cost-effective ultra-high resolution brain-dedicated PET scanner, using our depth-encoding Prism-PET detectors arranged along a compact and conformal gantry, showing substantial reduction in PVE and accurate radiotracer uptake quantification in small regions.<h4>Methods</h4>The decagon-shaped prototype scanner has a long diameter of 38.5 cm, a short diameter of 29.1 cm, and an axial field2023-01-01T00:00:00Z2023 Jan2025-04-26T08:04:28.738Z2025-04-06T12:35:10.091ZS-EPMC110256803665163010.1002/mp.16223