{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(4)"],"submitter":["Roschke NN"],"funding":["Charité – Universitätsmedizin Berlin, Charité 3R Research"],"pubmed_abstract":["<h4>Background</h4>Considering the expected increase in the elderly population and the growing emphasis on aging-related biomedical research, the demand for aged laboratory animals has surged, challenging established husbandry practices. Our objective was to establish a cost-effective method for environmental enrichment, utilizing the liver as a representative organ to assess potential metabolic changes in response to differing enrichment levels.<h4>Methods</h4>We conducted a six-month study involving 24 male Sprague Dawley rats, randomly assigned to four environmental enrichment groups. Two groups were housed in standard cages, while the others were placed in modified rabbit cages. Half of the groups received weekly playtime in an activity focused rat housing unit. We evaluated hormone le"],"journal":["PloS one"],"pagination":["e0297497"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11025844"],"repository":["biostudies-literature"],"pubmed_title":["Optimizing environmental enrichment for Sprague Dawley rats: Exemplary insights into the liver proteome."],"pmcid":["PMC11025844"],"pubmed_authors":["Moosburner S","Krenzien F","Roschke NN","Klein O","Polenz D","Sauer IM","Hillebrandt KH","Gassner JMGV","Raschzok N","Pratschke J"],"additional_accession":[]},"is_claimable":false,"name":"Optimizing environmental enrichment for Sprague Dawley rats: Exemplary insights into the liver proteome.","description":"<h4>Background</h4>Considering the expected increase in the elderly population and the growing emphasis on aging-related biomedical research, the demand for aged laboratory animals has surged, challenging established husbandry practices. Our objective was to establish a cost-effective method for environmental enrichment, utilizing the liver as a representative organ to assess potential metabolic changes in response to differing enrichment levels.<h4>Methods</h4>We conducted a six-month study involving 24 male Sprague Dawley rats, randomly assigned to four environmental enrichment groups. Two groups were housed in standard cages, while the others were placed in modified rabbit cages. Half of the groups received weekly playtime in an activity focused rat housing unit. We evaluated hormone le","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-05-29T09:46:22.976Z","creation":"2025-07-27T03:10:30.942Z"},"accession":"S-EPMC11025844","cross_references":{"pubmed":["38635534"],"doi":["10.1371/journal.pone.0297497"]}}