biostudies-literatureGibbons CHorizon 2020 Framework ProgrammeSteno Diabetes Center Copenhagen (SDCC)American Beverage AssociationHorizon 2020105005https://www.ebi.ac.uk/biostudies/studies/S-EPMC11026940biostudies-literatureUnknown102<h4>Background</h4>Sweeteners and sweetness enhancers (S&SE) are used to replace energy yielding sugars and maintain sweet taste in a wide range of products, but controversy exists about their effects on appetite and endocrine responses in reduced or no added sugar solid foods. The aim of the current study was to evaluate the acute (1 day) and repeated (two-week daily) ingestive effects of 2 S&SE vs. sucrose formulations of biscuit with fruit filling on appetite and endocrine responses in adults with overweight and obesity.<h4>Methods</h4>In a randomised crossover trial, 53 healthy adults (33 female, 20 male) with overweight/obesity in England and France consumed biscuits with fruit filling containing 1) sucrose, or reformulated with either 2) Stevia Rebaudioside M (StRebM) or 3) Neotame dEBioMedicineAcute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity-a randomised crossover trial from the SWEET consortium.PMC11026940774293SDCC 3.F CMPKjolbæk LRaben AScott CHarrold JARannou CMartinez JAFinlayson GWilton MBeaulieu KNavas-Carretero SMoshoyiannis HNazare JAHalford JCGGibbons CO'Hara BO'Connor DHardman CLe Bail AAlmiron-Roig EfalseAcute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity-a randomised crossover trial from the SWEET consortium.<h4>Background</h4>Sweeteners and sweetness enhancers (S&SE) are used to replace energy yielding sugars and maintain sweet taste in a wide range of products, but controversy exists about their effects on appetite and endocrine responses in reduced or no added sugar solid foods. The aim of the current study was to evaluate the acute (1 day) and repeated (two-week daily) ingestive effects of 2 S&SE vs. sucrose formulations of biscuit with fruit filling on appetite and endocrine responses in adults with overweight and obesity.<h4>Methods</h4>In a randomised crossover trial, 53 healthy adults (33 female, 20 male) with overweight/obesity in England and France consumed biscuits with fruit filling containing 1) sucrose, or reformulated with either 2) Stevia Rebaudioside M (StRebM) or 3) Neotame d2024-01-01T00:00:00Z2024 Apr2026-06-01T09:19:45.953Z2026-04-08T11:03:19.913ZS-EPMC110269403855326210.1016/j.ebiom.2024.105005