{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Deng Y"],"funding":["National Natural Science Foundation of China"],"pagination":["1355-1364"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11028128"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67(9)"],"pubmed_abstract":["Immune cell activation occurs concurrently with metabolic reprogramming. As important components of the tumor microenvironment, monocytic myeloid-derived suppressor cells (M-MDSCs) are featured by their potent immunosuppressive abilities on anti-tumor effector cells. However, little is known about the contribution of metabolic adaptations to their suppressive roles. In this study, we found that tumor-infiltrating M-MDSCs had the same phenotype with splenic M-MDSCs. Compared with splenic M-MDSCs, tumor-infiltrating M-MDSCs exhibited stronger suppressive activities which was accompanied by higher glycolysis. Inhibition of glycolysis impaired the suppressive function of tumor M-MDSCs. Meanwhile, the results demonstrated that mTOR was responsible for this function regulation. mTOR inhibition b"],"journal":["Cancer immunology, immunotherapy : CII"],"pubmed_title":["mTOR-mediated glycolysis contributes to the enhanced suppressive function of murine tumor-infiltrating monocytic myeloid-derived suppressor cells."],"pmcid":["PMC11028128"],"funding_grant_id":["81730045","91527305","31570892"],"pubmed_authors":["Yang J","Qian J","Zhang D","Chu Y","Luo F","Liu R","Yu H","Deng Y"],"additional_accession":[]},"is_claimable":false,"name":"mTOR-mediated glycolysis contributes to the enhanced suppressive function of murine tumor-infiltrating monocytic myeloid-derived suppressor cells.","description":"Immune cell activation occurs concurrently with metabolic reprogramming. As important components of the tumor microenvironment, monocytic myeloid-derived suppressor cells (M-MDSCs) are featured by their potent immunosuppressive abilities on anti-tumor effector cells. However, little is known about the contribution of metabolic adaptations to their suppressive roles. In this study, we found that tumor-infiltrating M-MDSCs had the same phenotype with splenic M-MDSCs. Compared with splenic M-MDSCs, tumor-infiltrating M-MDSCs exhibited stronger suppressive activities which was accompanied by higher glycolysis. Inhibition of glycolysis impaired the suppressive function of tumor M-MDSCs. Meanwhile, the results demonstrated that mTOR was responsible for this function regulation. mTOR inhibition b","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2025-04-22T20:45:41.968Z","creation":"2025-04-06T03:16:01.782Z"},"accession":"S-EPMC11028128","cross_references":{"pubmed":["29968153"],"doi":["10.1007/s00262-018-2177-1"]}}