biostudies-literatureFaiena IKite Pharma Inc.743-751https://www.ebi.ac.uk/biostudies/studies/S-EPMC11028196biostudies-literatureUnknown68(5)<h4>Background</h4>Melanoma-associated antigen-A (MAGE-A) and programmed-death ligand 1 (PD-L1) are present in urothelial carcinoma (UC). We assessed survival outcomes in patients with MAGE-A and PD-L1 expression.<h4>Methods</h4>MAGE-A and PD-L1 expression on neoplastic cells was analyzed using tissue microarrays from patients with UC. We compared differential expression between disease stage and grade. MAGE-A and PD-L1 co-expression was subcategorized. Fisher's exact test was done for categorical variables followed by univariable and multivariable analysis of recurrence-free survival (RFS) and progression-free survival (PFS).<h4>Results</h4>Co-expression of MAGE+/PD-L1+ was higher in advanced disease; however, only MAGE+/PD-L1- was associated with shorter RFS [hazard ratio (HR) 1.89; 95% Cancer immunology, immunotherapy : CIIMelanoma-associated antigen-A and programmed death-ligand 1 expression are associated with advanced urothelial carcinoma.PMC11028196SRA-2018-0493Jain RPantuck AJChamie KDrakaki AAstrow SHFaiena IElashoff DABot ABelldegrun ASfalseMelanoma-associated antigen-A and programmed death-ligand 1 expression are associated with advanced urothelial carcinoma.<h4>Background</h4>Melanoma-associated antigen-A (MAGE-A) and programmed-death ligand 1 (PD-L1) are present in urothelial carcinoma (UC). We assessed survival outcomes in patients with MAGE-A and PD-L1 expression.<h4>Methods</h4>MAGE-A and PD-L1 expression on neoplastic cells was analyzed using tissue microarrays from patients with UC. We compared differential expression between disease stage and grade. MAGE-A and PD-L1 co-expression was subcategorized. Fisher's exact test was done for categorical variables followed by univariable and multivariable analysis of recurrence-free survival (RFS) and progression-free survival (PFS).<h4>Results</h4>Co-expression of MAGE+/PD-L1+ was higher in advanced disease; however, only MAGE+/PD-L1- was associated with shorter RFS [hazard ratio (HR) 1.89; 95% 2019-01-01T00:00:00Z2019 May2026-06-01T09:17:19.924Z2026-04-08T11:05:51.955ZS-EPMC110281963079001510.1007/s00262-019-02316-w