{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin Z"],"funding":["Natural Science Fund of Jiangsu Province","Social development fund of Yangzhou municipality","National Natural Science Foundation of China","Collaborative Fund of Yangzhou University and Yangzhou municipality"],"pagination":["1159-1173"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11028319"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67(7)"],"pubmed_abstract":["Regulatory T cells play critical roles in self-tolerance and tumor evasion. CD4+NKG2D+ cells with regulatory activity are present in patients with NKG2DL+ tumors and juvenile systemic lupus erythematosus. We previously showed that TGF-β-producing CD4+NKG2D+ T cells are present in pCD86-Rae-1ε transgenic mice. Here, we performed both ex vivo and in vivo studies on pCD86-Rae-1ε transgenic mice and an MC38 tumor-bearing mouse model and show that NK1.1-CD4+NKG2D+ T cells have regulatory activity in pCD86-Rae-1ε transgenic mice. Furthermore, this T-cell subset was induced in mice transplanted with NKG2DL+ tumor cells and produced TGF-β and FasL, and secreted low amounts of IFN-γ. This T-cell subse"],"journal":["Cancer immunology, immunotherapy : CII"],"pubmed_title":["Regulatory NK1.1-CD4+NKG2D+ subset induced by NKG2DL+ cells promotes tumor evasion in mice."],"pmcid":["PMC11028319"],"funding_grant_id":["81273214","BK2011449","81671547","2012038-5","BK2008215","81172785","81471547","YZ2014179"],"pubmed_authors":["Qian X","Hu C","Ding Y","Zhang Y","Xiao W","Jia X","Lin Z","Zhu G","Han S","Qian L","Gong W"],"additional_accession":[]},"is_claimable":false,"name":"Regulatory NK1.1-CD4+NKG2D+ subset induced by NKG2DL+ cells promotes tumor evasion in mice.","description":"Regulatory T cells play critical roles in self-tolerance and tumor evasion. CD4+NKG2D+ cells with regulatory activity are present in patients with NKG2DL+ tumors and juvenile systemic lupus erythematosus. We previously showed that TGF-β-producing CD4+NKG2D+ T cells are present in pCD86-Rae-1ε transgenic mice. Here, we performed both ex vivo and in vivo studies on pCD86-Rae-1ε transgenic mice and an MC38 tumor-bearing mouse model and show that NK1.1-CD4+NKG2D+ T cells have regulatory activity in pCD86-Rae-1ε transgenic mice. Furthermore, this T-cell subset was induced in mice transplanted with NKG2DL+ tumor cells and produced TGF-β and FasL, and secreted low amounts of IFN-γ. This T-cell subse","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2025-04-22T20:40:31.833Z","creation":"2025-04-06T03:17:03.529Z"},"accession":"S-EPMC11028319","cross_references":{"pubmed":["29802426"],"doi":["10.1007/s00262-018-2172-6"]}}