{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["66(10)"],"submitter":["Battella S"],"funding":["ONLUS Sant&apos;Andrea","Associazione Italiana per la Ricerca sul Cancro","Ministero dell’Istruzione, dell’Università e della Ricerca"],"pubmed_abstract":["The importance of T cell-dependent immune responses in achieving long-term cure of chemoimmunotherapy-treated cancer patients is underscored by the recently described \"vaccinal effect\" exerted by therapeutic mAbs. In accordance, pre- and post-therapy peripheral blood lymphopenia represents a well-established negative prognostic factor in DLBCL. We analyzed the phenotypic and functional (IFNγ production, and Granzyme B (GrzB) cytotoxic granule marker expression) profile of peripheral blood T lymphocyte subsets (\"conventional\" CD4<sup>+</sup> and CD8<sup>+</sup>, FOXP3<sup>+</sup>CD25<sup>bright</sup> Treg, and \"innate-like\" CD56<sup>+</sup>) in DLBCL patients at diagnosis, and assessed the long-term impact of R-CHOP chemoimmunotherapy, in a prospective study. At diagnosis, DLBCL patients sh"],"journal":["Cancer immunology, immunotherapy : CII"],"pagination":["1295-1306"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11028700"],"repository":["biostudies-literature"],"pubmed_title":["Peripheral blood T cell alterations in newly diagnosed diffuse large B cell lymphoma patients and their long-term dynamics upon rituximab-based chemoimmunotherapy."],"pmcid":["PMC11028700"],"pubmed_authors":["Porzia A","Franchitti L","Palmieri G","La Scaleia R","Santoni A","Di Landro F","Mainiero F","Ruco L","Battella S","Di Napoli A","Cox MC","Monarca B"],"additional_accession":[]},"is_claimable":false,"name":"Peripheral blood T cell alterations in newly diagnosed diffuse large B cell lymphoma patients and their long-term dynamics upon rituximab-based chemoimmunotherapy.","description":"The importance of T cell-dependent immune responses in achieving long-term cure of chemoimmunotherapy-treated cancer patients is underscored by the recently described \"vaccinal effect\" exerted by therapeutic mAbs. In accordance, pre- and post-therapy peripheral blood lymphopenia represents a well-established negative prognostic factor in DLBCL. We analyzed the phenotypic and functional (IFNγ production, and Granzyme B (GrzB) cytotoxic granule marker expression) profile of peripheral blood T lymphocyte subsets (\"conventional\" CD4<sup>+</sup> and CD8<sup>+</sup>, FOXP3<sup>+</sup>CD25<sup>bright</sup> Treg, and \"innate-like\" CD56<sup>+</sup>) in DLBCL patients at diagnosis, and assessed the long-term impact of R-CHOP chemoimmunotherapy, in a prospective study. At diagnosis, DLBCL patients sh","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-22T20:42:36.369Z","creation":"2025-04-06T03:17:17.819Z"},"accession":"S-EPMC11028700","cross_references":{"pubmed":["28555258"],"doi":["10.1007/s00262-017-2026-7"]}}