{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(10)"],"submitter":["Winkler C"],"pubmed_abstract":["Cytotoxic T lymphocytes (CTL) can kill Hodgkin's lymphoma (HL) cells, and CTL have been used for the treatment of Epstein-Barr virus (EBV)-positive HL. For patients with EBV-negative HL, this strategy cannot be employed and alternative target structures have to be defined. In order to establish a system for the stimulation of HL-reactive T cells, we used dendritic cells (DC) as antigen-presenting cells for autologous T cells and transfected these DC with RNA from established HL cell lines. After stimulation of peripheral blood mononuclear cells (PBMC) with RNA-transfected DC, we analyzed the reactivity of primed PBMC by interferon gamma enzyme-linked immunospot. Our results suggest the presence of antigens with expression in HL cell lines and recognition of these antigens in combination wi"],"journal":["Cancer immunology, immunotherapy : CII"],"pagination":["1769-79"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11029013"],"repository":["biostudies-literature"],"pubmed_title":["Hodgkin's lymphoma RNA-transfected dendritic cells induce cancer/testis antigen-specific immune responses."],"pmcid":["PMC11029013"],"pubmed_authors":["Schlaf G","Max D","Altermann W","Banning-Eichenseer U","Kewitz S","Kornhuber M","Staege MS","Steingrube DS","Emmer A","Winkler C"],"additional_accession":[]},"is_claimable":false,"name":"Hodgkin's lymphoma RNA-transfected dendritic cells induce cancer/testis antigen-specific immune responses.","description":"Cytotoxic T lymphocytes (CTL) can kill Hodgkin's lymphoma (HL) cells, and CTL have been used for the treatment of Epstein-Barr virus (EBV)-positive HL. For patients with EBV-negative HL, this strategy cannot be employed and alternative target structures have to be defined. In order to establish a system for the stimulation of HL-reactive T cells, we used dendritic cells (DC) as antigen-presenting cells for autologous T cells and transfected these DC with RNA from established HL cell lines. After stimulation of peripheral blood mononuclear cells (PBMC) with RNA-transfected DC, we analyzed the reactivity of primed PBMC by interferon gamma enzyme-linked immunospot. Our results suggest the presence of antigens with expression in HL cell lines and recognition of these antigens in combination wi","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Oct","modification":"2026-06-01T23:56:27.046Z","creation":"2026-05-24T03:07:36.012Z"},"accession":"S-EPMC11029013","cross_references":{"pubmed":["22419371"],"doi":["10.1007/s00262-012-1239-z"]}}