{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garcia-Marquez MA"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["e007268"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11029431"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["<h4>Background</h4>The individual HLA-I genotype is associated with cancer, autoimmune diseases and infections. This study elucidates the role of germline homozygosity or allelic imbalance of HLA-I loci in esophago-gastric adenocarcinoma (EGA) and determines the resulting repertoires of potentially immunogenic peptides.<h4>Methods</h4>HLA genotypes and sequences of either (1) 10 relevant tumor-associated antigens (TAAs) or (2) patient-specific mutation-associated neoantigens (MANAs) were used to predict good-affinity binders using an in silico approach for MHC-binding (www.iedb.org). Imbalanced or lost expression of HLA-I-A/B/C alleles was analyzed by transcriptome sequencing. FluoroSpot assays and TCR sequencing were used to determine peptide-specific T-cell responses.<h4>Results</h4>We s"],"journal":["Journal for immunotherapy of cancer"],"pubmed_title":["Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides."],"pmcid":["PMC11029431"],"funding_grant_id":["No. 325827080 and No. 418074181"],"pubmed_authors":["George J","Peifer M","Muller P","Bruns C","Gathof B","Bauer E","Nikolic M","Yazbeck AM","Hillmer AM","von Bergwelt-Baildon M","Schloßer HA","Garcia-Marquez MA","Keller D","Wennhold K","Zander T","Schroder W","Thelen M","Thomas R","Quaas A","Lehmann J","Maas L"],"additional_accession":[]},"is_claimable":false,"name":"Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides.","description":"<h4>Background</h4>The individual HLA-I genotype is associated with cancer, autoimmune diseases and infections. This study elucidates the role of germline homozygosity or allelic imbalance of HLA-I loci in esophago-gastric adenocarcinoma (EGA) and determines the resulting repertoires of potentially immunogenic peptides.<h4>Methods</h4>HLA genotypes and sequences of either (1) 10 relevant tumor-associated antigens (TAAs) or (2) patient-specific mutation-associated neoantigens (MANAs) were used to predict good-affinity binders using an in silico approach for MHC-binding (www.iedb.org). Imbalanced or lost expression of HLA-I-A/B/C alleles was analyzed by transcriptome sequencing. FluoroSpot assays and TCR sequencing were used to determine peptide-specific T-cell responses.<h4>Results</h4>We s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-15T06:15:49.253Z","creation":"2026-06-15T03:08:39.132Z"},"accession":"S-EPMC11029431","cross_references":{"pubmed":["38631707"],"doi":["10.1136/jitc-2023-007268"]}}