biostudies-literatureUnknownSun FNIA NIH HHSDuring mammalian reproduction, sperm are delivered to the female reproductive tract bathed in a complex medium known as seminal fluid, which plays key roles in signaling to the female reproductive tract and in nourishing sperm for their onwards journey. Along with minor contributions from the prostate and the epididymis, the majority of seminal fluid is produced by a somewhat understudied organ known as the seminal vesicle. Here, we report the first single-cell RNA-seq atlas of the mouse seminal vesicle, generated using tissues obtained from 23 mice of varying ages, exposed to a range of dietary challenges. We define the transcriptome of the secretory cells in this tissue, identifying a relatively homogeneous population of the epithelial cells which are responsible for producing the majoribioRxiv : the preprint server for biology2024.04.08.588538https://www.ebi.ac.uk/biostudies/studies/S-EPMC11030459biostudies-literatureA single cell atlas of the mouse seminal vesicle.PMC11030459R01 AG073238Galan CRinaldi VGladyshev VNGarber MDesevin KFu YYang CHParameswaran SKrietenstein NSchjenken JEShindyapina AVRando OJYin QSun FManukyan AMayall JfalseA single cell atlas of the mouse seminal vesicle.During mammalian reproduction, sperm are delivered to the female reproductive tract bathed in a complex medium known as seminal fluid, which plays key roles in signaling to the female reproductive tract and in nourishing sperm for their onwards journey. Along with minor contributions from the prostate and the epididymis, the majority of seminal fluid is produced by a somewhat understudied organ known as the seminal vesicle. Here, we report the first single-cell RNA-seq atlas of the mouse seminal vesicle, generated using tissues obtained from 23 mice of varying ages, exposed to a range of dietary challenges. We define the transcriptome of the secretory cells in this tissue, identifying a relatively homogeneous population of the epithelial cells which are responsible for producing the majori2024-01-01T00:00:00Z2024 Apr2026-05-23T03:16:56.692Z2025-04-06T03:17:37.781ZS-EPMC110304593864509010.1101/2024.04.08.588538