{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Scazufca M"],"funding":["Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico","Medical Research Council","RCUK | Medical Research Council","Fundação de Amparo à Pesquisa do Estado de São Paulo","Wellcome Trust"],"pagination":["1127-1133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11031393"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(4)"],"pubmed_abstract":["Scalable solutions to treat depression in older adults in low-resourced settings are urgently needed. The PRODIGITAL-D pragmatic, single-blind, two-arm, individually randomized controlled trial assessed the effectiveness of a mobile messaging psychosocial intervention in improving depressive symptomatology among older adults in socioeconomically deprived areas of Guarulhos, Brazil. Older adults (aged 60+ years) registered with 24 primary care clinics and identified with depressive symptomatology (9-item Patient Health Questionnaire (PHQ-9) scores ≥ 10) received the 6-week Viva Vida intervention based on psychoeducation and behavioral activation (n = 298) or a single message (n = 305). No health professional support was offered. The primary outcome was improvement from depressive symptomatology (PHQ-9 < 10) at 3 months. Of the 603 participants enrolled (mean age = 65.1 years; 451 (74.8%) women), 527 (87.4%) completed the follow-up assessment. In the intervention arm, 109 of 257 (42.4%) participants had an improved depressive symptomatology, compared with 87 of 270 (32.2%) participants in the control arm (adjusted odds ratio = 1.57; 95% confidence interval = 1.07-2.29; P = 0.019). No severe adverse events related to trial participation were observed. These results demonstrate the usefulness of a digital messaging psychosocial intervention in the short-term improvement from depressive symptomatology that can potentially be integrated into primary care programs for treating older adults with depression. Brazilian Registry of Clinical Trials registration: ReBEC ( RBR-4c94dtn )."],"journal":["Nature medicine"],"pubmed_title":["Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial."],"pmcid":["PMC11031393"],"funding_grant_id":["2020/14768-1","2018/19343-9","2017/50094–2","2021/10148-1","2022/05107-7","2020/14504-4","2022/08668-0","307579/2019-0","2021/03849-3","2020/02272-1","MR/R006229/1","2021/04493-8","2021/04230-7"],"pubmed_authors":["Hollingworth W","Didone TVN","Moretti FA","Scazufca M","Araya R","Oliveira da Costa M","Queiroz de Souza CH","Pereira LA","Mendes de Sa Martins M","Nakamura CA","Seward N","Peters TJ","Macias de Oliveira G","Souza Dos Santos M","van de Ven P"],"additional_accession":[]},"is_claimable":false,"name":"Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial.","description":"Scalable solutions to treat depression in older adults in low-resourced settings are urgently needed. The PRODIGITAL-D pragmatic, single-blind, two-arm, individually randomized controlled trial assessed the effectiveness of a mobile messaging psychosocial intervention in improving depressive symptomatology among older adults in socioeconomically deprived areas of Guarulhos, Brazil. Older adults (aged 60+ years) registered with 24 primary care clinics and identified with depressive symptomatology (9-item Patient Health Questionnaire (PHQ-9) scores ≥ 10) received the 6-week Viva Vida intervention based on psychoeducation and behavioral activation (n = 298) or a single message (n = 305). No health professional support was offered. The primary outcome was improvement from depressive symptomatology (PHQ-9 < 10) at 3 months. Of the 603 participants enrolled (mean age = 65.1 years; 451 (74.8%) women), 527 (87.4%) completed the follow-up assessment. In the intervention arm, 109 of 257 (42.4%) participants had an improved depressive symptomatology, compared with 87 of 270 (32.2%) participants in the control arm (adjusted odds ratio = 1.57; 95% confidence interval = 1.07-2.29; P = 0.019). No severe adverse events related to trial participation were observed. These results demonstrate the usefulness of a digital messaging psychosocial intervention in the short-term improvement from depressive symptomatology that can potentially be integrated into primary care programs for treating older adults with depression. Brazilian Registry of Clinical Trials registration: ReBEC ( RBR-4c94dtn ).","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-04T12:47:36.842Z","creation":"2025-04-04T12:47:36.842Z"},"accession":"S-EPMC11031393","cross_references":{"pubmed":["38486075"],"doi":["10.1038/s41591-024-02864-4"]}}