{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(4)"],"submitter":["Zhang P"],"pubmed_abstract":["Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are unclear. Here we show that activation of S6K specifically in Drosophila fat-body blocked extension of lifespan by rapamycin, induced accumulation of multilamellar lysosomes and blocked age-associated hyperactivation of the NF-κB-like immune deficiency (IMD) pathway, indicative of reduced inflammaging. Syntaxin 13 mediated the effects of TORC1-S6K signaling on lysosome morphology and inflammaging, suggesting they may be linked. Inflammaging depended on the IMD receptor regulatory isoform PGRP-LC, and repression of the IMD pathway from midlife extended lifespan. Age-related inflammaging was higher in females than in "],"journal":["Nature aging"],"pagination":["491-509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11031405"],"repository":["biostudies-literature"],"pubmed_title":["Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system."],"pmcid":["PMC11031405"],"pubmed_authors":["Gronke S","Partridge L","Zhang P","Catterson JH"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.","description":"Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are unclear. Here we show that activation of S6K specifically in Drosophila fat-body blocked extension of lifespan by rapamycin, induced accumulation of multilamellar lysosomes and blocked age-associated hyperactivation of the NF-κB-like immune deficiency (IMD) pathway, indicative of reduced inflammaging. Syntaxin 13 mediated the effects of TORC1-S6K signaling on lysosome morphology and inflammaging, suggesting they may be linked. Inflammaging depended on the IMD receptor regulatory isoform PGRP-LC, and repression of the IMD pathway from midlife extended lifespan. Age-related inflammaging was higher in females than in ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-01T21:20:30.893Z","creation":"2026-05-21T03:08:15.964Z"},"accession":"S-EPMC11031405","cross_references":{"pubmed":["38413780"],"doi":["10.1038/s43587-024-00578-3"]}}