{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Y"],"funding":["National Natural Science Foundation of China"],"pagination":["302"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11031446"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108(1)"],"pubmed_abstract":["Alternative splicing (AS) greatly expands the protein diversity in eukaryotes. Although AS variants have been frequently reported existing in filamentous fungi, it remains unclear whether lignocellulose-degrading enzyme genes in industrially important fungi undergo AS events. In this work, AS events of lignocellulose-degrading enzymes genes in Aspergillus niger under two carbon sources (glucose and wheat straw) were investigated by RNA-Seq. The results showed that a total of 23 out of the 56 lignocellulose-degrading enzyme genes had AS events and intron retention was the main type of these AS events. The AS variant enzymes from the annotated endo-β-1,4-xylanase F1 gene (xynF1) and the endo-β-1,4-glucanase D gene (eglD), noted as XYNF1-AS and EGLD-AS, were characterized compared to their no"],"journal":["Applied microbiology and biotechnology"],"pubmed_title":["Alternative splicing analysis of lignocellulose-degrading enzyme genes and enzyme variants in Aspergillus niger."],"pmcid":["PMC11031446"],"funding_grant_id":["32171476"],"pubmed_authors":["Liu X","Dong F","Wang R","Ajmal M","Lin H","Chen H","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Alternative splicing analysis of lignocellulose-degrading enzyme genes and enzyme variants in Aspergillus niger.","description":"Alternative splicing (AS) greatly expands the protein diversity in eukaryotes. Although AS variants have been frequently reported existing in filamentous fungi, it remains unclear whether lignocellulose-degrading enzyme genes in industrially important fungi undergo AS events. In this work, AS events of lignocellulose-degrading enzymes genes in Aspergillus niger under two carbon sources (glucose and wheat straw) were investigated by RNA-Seq. The results showed that a total of 23 out of the 56 lignocellulose-degrading enzyme genes had AS events and intron retention was the main type of these AS events. The AS variant enzymes from the annotated endo-β-1,4-xylanase F1 gene (xynF1) and the endo-β-1,4-glucanase D gene (eglD), noted as XYNF1-AS and EGLD-AS, were characterized compared to their no","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-01T21:19:51.953Z","creation":"2026-05-21T03:08:11.689Z"},"accession":"S-EPMC11031446","cross_references":{"pubmed":["38639796"],"doi":["10.1007/s00253-024-13137-y"]}}