{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rouphael NG"],"funding":["BLRD VA","US government","NCATS NIH HHS","NIAID NIH HHS","Department of Health and Human Services","National Institutes of Health","NIH","Office of the Assistant Secretary for Preparedness and Response","CLC NIH HHS","HHS","Biomedical Advanced Research and Development Authority","National Cancer Institute","Division of Microbiology and Infectious Diseases"],"pagination":["1662-1666"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11032204"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["228(12)"],"pubmed_abstract":["We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost."],"journal":["The Journal of infectious diseases"],"pubmed_title":["Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial."],"pmcid":["PMC11032204"],"funding_grant_id":["UM1 AI148450","R01 AI165818","UM1 AI148575","UL1 TR002378","UM1 AI148576","UM1 AI148685","R01AI165818","C0000008","75N91019D00024","I01 BX000207","75N91022F00007","75N93021C00014","75A50122C00008","75N93021C00012","UM1 AI069432"],"pubmed_authors":["Desrosiers A","Hoang B","Post DJ","McQuarrie LJ","Linton JE","Engelson C","Baughman H","Arega J","Siegel M","Nayak SU","Novak RM","Winokur PL","Maxwell C","Tong A","Ladner BG","Walsh E","Mahgoub SM","Curtin D","Walsh SR","Babu TM","Wiley Z","Baden LR","Chan A","Krause T","Smith DJ","Carste B","Griffith CJ","Smith MJ","Presti RM","Roberts PC","Mulligan MJ","El Sahly HM","McDonald WL","Rooks R","Goepfert PA","Atmar RL","Neuzil KM","Eaton A","Walter EB","Martin TCS","Meier J","Beigel JH","Lewis TC","Posavad CM","Losada C","Tureli S","Kingsley P","Herrick J","Diemert DJ","DeGrace MM","Backer M","Oikonomopoulou Z","Kottkamp AC","Makowski M","Peasley M","Hoopengardner LB","Rouphael NG","Fusco DN","Hendrickx S","Whitaker JA","Wald A","Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team","Jackson LA","Drouin AC","Moody MA","McNeil L","Elsafy M","Stapleton J","Young SP","Peters E","Rupp R","Koo H","Sherman AC","Davis T","Schmader KE","Marrazzo J","Brown E","Graciaa DS","Frey SE","McQuarrie L","Stephens DS","Falsey AR","Fleming AB","Meagher MA","Telu K","Pikaart-Tautges R","Carter N","Hill H","Abebe K","Graham I","Healy CM","Abate G","Samaha H","Bethony JM","Little SJ","Hoft DF","Lyke KE","Engel TM","Soma V","O'Halloran JA","Luetkemeyer AF","Makhene M","Joseph S","Dunstan M","Lennox J","Netzl A","Wilks SH","Rostad CA","Immergluck LC","Gale M","Kamidani S","Anderson EJ","Burkey AE","Mu J","Rebolledo PA","Keitel WA","Montefiori DC","Johnson E","Porterfield L","Hauge K","Giebeig LA","Malkin E","Lau R","Crandon S","Branche AR","Wendrow A","Numbi FK","Makhene MK","Thompson RM","Gettinger NL","Harris C","Farley MM","Albert J","Lopez AM","Shami S","Sindall E","McElrath J"],"additional_accession":[]},"is_claimable":false,"name":"Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.","description":"We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-06-02T11:19:58.714Z","creation":"2025-04-03T21:31:01.691Z"},"accession":"S-EPMC11032204","cross_references":{"pubmed":["37561027"],"doi":["10.1093/infdis/jiad323"]}}