biostudies-literatureRouphael NGBLRD VAUS governmentNCATS NIH HHSNIAID NIH HHSDepartment of Health and Human ServicesNational Institutes of HealthNIHOffice of the Assistant Secretary for Preparedness and ResponseCLC NIH HHSHHSBiomedical Advanced Research and Development AuthorityNational Cancer InstituteDivision of Microbiology and Infectious Diseases1662-1666https://www.ebi.ac.uk/biostudies/studies/S-EPMC11032204biostudies-literatureUnknown228(12)We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.The Journal of infectious diseasesImmunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.PMC11032204UM1 AI148450R01 AI165818UM1 AI148575UL1 TR002378UM1 AI148576UM1 AI148685R01AI165818C000000875N91019D00024I01 BX00020775N91022F0000775N93021C0001475A50122C0000875N93021C00012UM1 AI069432Desrosiers AHoang BPost DJMcQuarrie LJLinton JEEngelson CBaughman HArega JSiegel MNayak SUNovak RMWinokur PLMaxwell CTong ALadner BGWalsh EMahgoub SMCurtin DWalsh SRBabu TMWiley ZBaden LRChan AKrause TSmith DJCarste BGriffith CJSmith MJPresti RMRoberts PCMulligan MJEl Sahly HMMcDonald WLRooks RGoepfert PAAtmar RLNeuzil KMEaton AWalter EBMartin TCSMeier JBeigel JHLewis TCPosavad CMLosada CTureli SKingsley PHerrick JDiemert DJDeGrace MMBacker MOikonomopoulou ZKottkamp ACMakowski MPeasley MHoopengardner LBRouphael NGFusco DNHendrickx SWhitaker JAWald ACoronavirus Variant Immunologic Landscape Trial (COVAIL) Study TeamJackson LADrouin ACMoody MAMcNeil LElsafy MStapleton JYoung SPPeters ERupp RKoo HSherman ACDavis TSchmader KEMarrazzo JBrown EGraciaa DSFrey SEMcQuarrie LStephens DSFalsey ARFleming ABMeagher MATelu KPikaart-Tautges RCarter NHill HAbebe KGraham IHealy CMAbate GSamaha HBethony JMLittle SJHoft DFLyke KEEngel TMSoma VO'Halloran JALuetkemeyer AFMakhene MJoseph SDunstan MLennox JNetzl AWilks SHRostad CAImmergluck LCGale MKamidani SAnderson EJBurkey AEMu JRebolledo PAKeitel WAMontefiori DCJohnson EPorterfield LHauge KGiebeig LAMalkin ELau RCrandon SBranche ARWendrow ANumbi FKMakhene MKThompson RMGettinger NLHarris CFarley MMAlbert JLopez AMShami SSindall EMcElrath JfalseImmunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.2023-01-01T00:00:00Z2023 Dec2026-06-02T11:19:58.714Z2025-04-03T21:31:01.691ZS-EPMC110322043756102710.1093/infdis/jiad323