{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xing H"],"funding":["Consejo Nacional de Investigaciones Científicas y Técnicas","US-Egypt Joint Board on Scientific and Technological Cooperation (U.S. - Egypt Joint Board)","US-Egypt Joint Board on Scientific and Technological Cooperation","National Science Foundation (NSF)","Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)","National Science Foundation"],"pagination":["e2321498121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11032466"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(16)"],"pubmed_abstract":["In recent decades, peptide amphiphiles (PAs) have established themselves as promising self-assembling bioinspired materials in a wide range of medical fields. Herein, we report a dual-therapeutic system constituted by an antimicrobial PA and a cylindrical protease inhibitor (LJC) to achieve broad antimicrobial spectrum and to enhance therapeutic efficacy. We studied two strategies: PA-LJC nanostructures (<i>Encapsulation</i>) and PA nanostructures + free LJC (<i>Combination</i>). Computational modeling using a molecular theory for amphiphile self-assembly captures and explains the morphology of PA-LJC nanostructures and the location of encapsulated LJC in agreement with transmission electron microscopy and two-dimensional (2D) NMR observations. The morphology and release profile of PA-LJC "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Engineering a nanoantibiotic system displaying dual mechanism of action."],"pmcid":["PMC11032466"],"funding_grant_id":["ANPCyT PICT 1520-2019","72026321CA00001","DMR-1941731"],"pubmed_authors":["Conda-Sheridan M","de Campos LJ","Xing H","Pereira AJ","Fiora MM","Tagliazucchi M","Aguiar-Alves F"],"additional_accession":[]},"is_claimable":false,"name":"Engineering a nanoantibiotic system displaying dual mechanism of action.","description":"In recent decades, peptide amphiphiles (PAs) have established themselves as promising self-assembling bioinspired materials in a wide range of medical fields. Herein, we report a dual-therapeutic system constituted by an antimicrobial PA and a cylindrical protease inhibitor (LJC) to achieve broad antimicrobial spectrum and to enhance therapeutic efficacy. We studied two strategies: PA-LJC nanostructures (<i>Encapsulation</i>) and PA nanostructures + free LJC (<i>Combination</i>). Computational modeling using a molecular theory for amphiphile self-assembly captures and explains the morphology of PA-LJC nanostructures and the location of encapsulated LJC in agreement with transmission electron microscopy and two-dimensional (2D) NMR observations. The morphology and release profile of PA-LJC ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-18T19:43:59.875Z","creation":"2025-04-07T07:29:51.483Z"},"accession":"S-EPMC11032466","cross_references":{"pubmed":["38593077"],"doi":["10.1073/pnas.2321498121"]}}