{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qin Y"],"funding":["the Project of Jiangsu Provincial Medical Youth Talent","\"2015\" Cultivation Program for Reserve Talents for Academic Leaders of Nanjing Stomatological School, Medical School of Nanjing University","\"3456\" Cultivation Program for Junior Talents of Nanjing Stomatological School, Medical School of Nanjing University","National Natural Scientific Foundation of China","China Postdoctoral Science Foundation","“3456” Cultivation Program for Junior Talents of Nanjing Stomatological School, Medical School of Nanjing University","Medical Science and Technology Development Foundation of Nanjing Department of Health","“2015” Cultivation Program for Reserve Talents for Academic Leaders of Nanjing Stomatological School, Medical School of Nanjing University"],"pagination":["206"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11033248"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["150(4)"],"pubmed_abstract":["Purpose
Periodontitis-associated bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, are closely linked to the risk of oral squamous cell carcinoma (OSCC). Emerging studies have indicated that another common periodontal pathogen, Prevotella intermedia (P. intermedia), is enriched in OSCC and could affect the occurrence and progression of OSCC. Our aim is to determine the effects of P. intermedia on the progression of OSCC and the role of antibiotics in reversing these effects.Methods
In this study, a murine xenograft model of OSCC was established, and the mice were injected intratumorally with PBS (control group), P. intermedia (P.i group), or P. intermedia combined with an antibiotic cocktail administration (P.i + ABX group), respectively. The effects o"],"journal":["Journal of cancer research and clinical oncology"],"pubmed_title":["Prevotella intermedia boosts OSCC progression through ISG15 upregulation: a new target for intervention."],"pmcid":["PMC11033248"],"funding_grant_id":["0222R213 and 0222C116","QNRC2016118","81870767 and 82103304","2023M741767","ZKX23054","0223A210"],"pubmed_authors":["Liu H","Duan N","Qin Y","Zhang L","Liu T","Zhou Y","Li Z","Ye P","Wang S","Peng Q","Ma J","Wang W","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Prevotella intermedia boosts OSCC progression through ISG15 upregulation: a new target for intervention.","description":"Purpose
Periodontitis-associated bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, are closely linked to the risk of oral squamous cell carcinoma (OSCC). Emerging studies have indicated that another common periodontal pathogen, Prevotella intermedia (P. intermedia), is enriched in OSCC and could affect the occurrence and progression of OSCC. Our aim is to determine the effects of P. intermedia on the progression of OSCC and the role of antibiotics in reversing these effects.Methods
In this study, a murine xenograft model of OSCC was established, and the mice were injected intratumorally with PBS (control group), P. intermedia (P.i group), or P. intermedia combined with an antibiotic cocktail administration (P.i + ABX group), respectively. The effects o","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-01T09:20:37.058Z","creation":"2026-04-08T11:06:02.387Z"},"accession":"S-EPMC11033248","cross_references":{"pubmed":["38644421"],"doi":["10.1007/s00432-024-05730-5"]}}