{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["143(14)"],"submitter":["Bastian L"],"pubmed_abstract":["<h4>Abstract</h4>Distinct diagnostic entities within BCR::ABL1-positive acute lymphoblastic leukemia (ALL) are currently defined by the International Consensus Classification of myeloid neoplasms and acute leukemias (ICC): \"lymphoid only\", with BCR::ABL1 observed exclusively in lymphatic precursors, vs \"multilineage\", where BCR::ABL1 is also present in other hematopoietic lineages. Here, we analyzed transcriptomes of 327 BCR::ABL1-positive patients with ALL (age, 2-84 years; median, 46 years) and identified 2 main gene expression clusters reproducible across 4 independent patient cohorts. Fluorescence in situ hybridization analysis of fluorescence-activated cell-sorted hematopoietic compartments showed distinct BCR::ABL1 involvement in myeloid cells for these clusters (n = 18/18 vs n = 3/1"],"journal":["Blood"],"pagination":["1391-1398"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11033585"],"repository":["biostudies-literature"],"pubmed_title":["Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL."],"pmcid":["PMC11033585"],"pubmed_authors":["Gokbuget N","Wittig M","Bastian L","Wolgast N","Hartmann AM","Zimmermann J","Neumann M","Baldus CD","Haferlach C","Brandl B","Das Gupta D","Chitadze G","Denker M","Faul C","Bruggemann M","Stelljes M","Schneller F","Bendig S","Schwartz S","Muller FJ","Fiedler W","Beder T","Steffen B","Pfeifer H","Barz MJ","Iben K","Harder L","Bartsch L","Rohrandt C","Walter W","Hansen BT","Cario G"],"additional_accession":[]},"is_claimable":false,"name":"Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL.","description":"<h4>Abstract</h4>Distinct diagnostic entities within BCR::ABL1-positive acute lymphoblastic leukemia (ALL) are currently defined by the International Consensus Classification of myeloid neoplasms and acute leukemias (ICC): \"lymphoid only\", with BCR::ABL1 observed exclusively in lymphatic precursors, vs \"multilineage\", where BCR::ABL1 is also present in other hematopoietic lineages. Here, we analyzed transcriptomes of 327 BCR::ABL1-positive patients with ALL (age, 2-84 years; median, 46 years) and identified 2 main gene expression clusters reproducible across 4 independent patient cohorts. Fluorescence in situ hybridization analysis of fluorescence-activated cell-sorted hematopoietic compartments showed distinct BCR::ABL1 involvement in myeloid cells for these clusters (n = 18/18 vs n = 3/1","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-01T09:20:47.097Z","creation":"2026-04-08T11:06:20.44Z"},"accession":"S-EPMC11033585","cross_references":{"pubmed":["38153913"],"doi":["10.1182/blood.2023021752"]}}