biostudies-literatureHarvey TNNorges Forskningsråde0302388https://www.ebi.ac.uk/biostudies/studies/S-EPMC11034671biostudies-literatureUnknown19(4)The anadromous Atlantic salmon undergo a preparatory physiological transformation before seawater entry, referred to as smoltification. Key molecular developmental processes involved in this life stage transition, such as remodeling of gill functions, are known to be synchronized and modulated by environmental cues like photoperiod. However, little is known about the photoperiod influence and genome regulatory processes driving other canonical aspects of smoltification such as the large-scale changes in lipid metabolism and energy homeostasis in the developing smolt liver. Here we generate transcriptome, DNA methylation, and chromatin accessibility data from salmon livers across smoltification under different photoperiod regimes. We find a systematic reduction of expression levels of genesPloS oneThe genome regulatory landscape of Atlantic salmon liver through smoltification.PMC11034671248792244164Gillard GBRosæg LLHarvey TNVik JOGrammes FMonsen OSandve SRHvidsten TRfalseThe genome regulatory landscape of Atlantic salmon liver through smoltification.The anadromous Atlantic salmon undergo a preparatory physiological transformation before seawater entry, referred to as smoltification. Key molecular developmental processes involved in this life stage transition, such as remodeling of gill functions, are known to be synchronized and modulated by environmental cues like photoperiod. However, little is known about the photoperiod influence and genome regulatory processes driving other canonical aspects of smoltification such as the large-scale changes in lipid metabolism and energy homeostasis in the developing smolt liver. Here we generate transcriptome, DNA methylation, and chromatin accessibility data from salmon livers across smoltification under different photoperiod regimes. We find a systematic reduction of expression levels of genes2024-01-01T00:00:00Z20242026-06-01T09:19:52.938Z2026-04-08T11:03:38.429ZS-EPMC110346713864820710.1371/journal.pone.0302388