{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Field MR"],"funding":["NCATS NIH HHS","NIAID NIH HHS"],"pagination":["e2023063480"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11035155"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["153(5)"],"pubmed_abstract":["<h4>Background and objectives</h4>Time to clinical stability (TCS) is a commonly used outcome in adults with community-acquired pneumonia (CAP), yet few studies have evaluated TCS in children. Our objective was to determine the association between TCS and disease severity in children with suspected CAP, as well as factors associated with reaching early stability.<h4>Methods</h4>This is a prospective cohort study of children (aged 3 months to 18 years) hospitalized with suspected CAP. TCS parameters included temperature, heart rate, respiratory rate, and hypoxemia with the use of supplemental oxygen. TCS was defined as time from admission to parameter normalization. The association of TCS with severity and clinical factors associated with earlier TCS were evaluated.<h4>Results</h4>Of 571 ch"],"journal":["Pediatrics"],"pubmed_title":["Time to Clinical Stability in Children With Community-Acquired Pneumonia."],"pmcid":["PMC11035155"],"funding_grant_id":["KL2 TR000078","K23 AI121325","K01 AI125413","R03 AI147112"],"pubmed_authors":["Field MR","Ruddy RM","Florin TA","Ambroggio L","Shah SS","Lorenz D"],"additional_accession":[]},"is_claimable":false,"name":"Time to Clinical Stability in Children With Community-Acquired Pneumonia.","description":"<h4>Background and objectives</h4>Time to clinical stability (TCS) is a commonly used outcome in adults with community-acquired pneumonia (CAP), yet few studies have evaluated TCS in children. Our objective was to determine the association between TCS and disease severity in children with suspected CAP, as well as factors associated with reaching early stability.<h4>Methods</h4>This is a prospective cohort study of children (aged 3 months to 18 years) hospitalized with suspected CAP. TCS parameters included temperature, heart rate, respiratory rate, and hypoxemia with the use of supplemental oxygen. TCS was defined as time from admission to parameter normalization. The association of TCS with severity and clinical factors associated with earlier TCS were evaluated.<h4>Results</h4>Of 571 ch","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-07-04T03:05:46.654Z","creation":"2025-07-04T03:05:46.654Z"},"accession":"S-EPMC11035155","cross_references":{"pubmed":["38618659"],"doi":["10.1542/peds.2023-063480"]}}