biostudies-literatureUnknown11Chen B<h4>Objective</h4>Although several observational studies have linked serum albumin to cardiovascular disease and considered it as an important biomarker, little is known about whether increasing or maintaining serum albumin levels can effectively improve the prognosis of patients with atrial fibrillation. Therefore, this study aims to further explore the causal relationship between serum albumin and atrial fibrillation and its potential mechanism.<h4>Method</h4>Using data from large-scale genome-wide association studies, we conducted a two-sample Mendelian randomization (MR) analysis and a mediation MR analysis, using serum albumin as the exposure variable and atrial fibrillation as the outcome variable. We included 486 serum metabolites as potential mediating factors. To increase the robuFrontiers in cardiovascular medicine1385223https://www.ebi.ac.uk/biostudies/studies/S-EPMC11035896biostudies-literatureSerum albumin levels and risk of atrial fibrillation: a Mendelian randomization study.PMC11035896Li WWang CChen BfalseSerum albumin levels and risk of atrial fibrillation: a Mendelian randomization study.<h4>Objective</h4>Although several observational studies have linked serum albumin to cardiovascular disease and considered it as an important biomarker, little is known about whether increasing or maintaining serum albumin levels can effectively improve the prognosis of patients with atrial fibrillation. Therefore, this study aims to further explore the causal relationship between serum albumin and atrial fibrillation and its potential mechanism.<h4>Method</h4>Using data from large-scale genome-wide association studies, we conducted a two-sample Mendelian randomization (MR) analysis and a mediation MR analysis, using serum albumin as the exposure variable and atrial fibrillation as the outcome variable. We included 486 serum metabolites as potential mediating factors. To increase the robu2024-01-01T00:00:00Z20242026-04-22T03:28:00.899Z2026-04-22T03:13:23.087ZS-EPMC110358963865549510.3389/fcvm.2024.1385223