{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kezlarian B"],"funding":["NCI NIH HHS"],"pagination":["526-534"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11037264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["131(8)"],"pubmed_abstract":["<h4>Introduction</h4>Although alterations in SMARCA4-deficient occur in non-small cell lung carcinoma (SD-NSCLC), thoracic SMARCA4-deficient undifferentiated tumor (TSDUT) is recognized as a distinct entity in the 2021 World Health Organization Classification of Thoracic Tumors because of unique morphologic, immunophenotypic and molecular features, and worse survival compared with SD-NSCLC. Cytologic diagnosis of TSDUT is clinically important because of its aggressive behavior and because it is often diagnosed by fine-needle aspiration because TSDUTs are usually unresectable at presentation. Here, we identify cytologic features that can be used for recognition of TSDUT and distinction from SD-NSCLC.<h4>Materials and methods</h4>Cytomorphologic features were investigated in cytology specime"],"journal":["Cancer cytopathology"],"pubmed_title":["Diagnosis of thoracic SMARCA4-deficient undifferentiated tumor in cytology."],"pmcid":["PMC11037264"],"funding_grant_id":["P30 CA008748"],"pubmed_authors":["White C","Sauter JL","Riedel E","Kezlarian B","Montecalvo J","Bodd FM","Chang JC","Rekhtman N"],"additional_accession":[]},"is_claimable":false,"name":"Diagnosis of thoracic SMARCA4-deficient undifferentiated tumor in cytology.","description":"<h4>Introduction</h4>Although alterations in SMARCA4-deficient occur in non-small cell lung carcinoma (SD-NSCLC), thoracic SMARCA4-deficient undifferentiated tumor (TSDUT) is recognized as a distinct entity in the 2021 World Health Organization Classification of Thoracic Tumors because of unique morphologic, immunophenotypic and molecular features, and worse survival compared with SD-NSCLC. Cytologic diagnosis of TSDUT is clinically important because of its aggressive behavior and because it is often diagnosed by fine-needle aspiration because TSDUTs are usually unresectable at presentation. Here, we identify cytologic features that can be used for recognition of TSDUT and distinction from SD-NSCLC.<h4>Materials and methods</h4>Cytomorphologic features were investigated in cytology specime","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-19T20:45:38.594Z","creation":"2025-04-19T20:45:38.594Z"},"accession":"S-EPMC11037264","cross_references":{"pubmed":["37278102"],"doi":["10.1002/cncy.22709"]}}