{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(5)"],"submitter":["Wegrzyniak O"],"funding":["European Foundation for the Study of Diabetes","Barndiabetesfondens","Magnus Bergvall Foundation","Swedish Research Council"],"pubmed_abstract":["Non-invasive assessment of fibrogenic activity, rather than fibrotic scars, could significantly improve the management of fibrotic diseases and the development of anti-fibrotic drugs. This study explores the potential of an Affibody molecule (Z09591) labeled with the Al(18)F-restrained complexing agent (RESCA) method as a tracer for the non-invasive detection of fibrogenic cells. Z09591 was functionalized with the RESCA chelator for direct labeling with [<sup>18</sup>F]AlF. <i>In vivo</i> positron emission tomography/magnetic resonance imaging scans on U-87 tumor-bearing mice exhibited high selectivity of the resulting radiotracer, [<sup>18</sup>F]AlF-RESCA-Z09591, for platelet-derived growth factor receptor β (PDGFRβ), with minimal non-specific background uptake. Evaluation in a mouse mod"],"journal":["iScience"],"pagination":["109688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11039342"],"repository":["biostudies-literature"],"pubmed_title":["Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule."],"pmcid":["PMC11039342"],"pubmed_authors":["Persson J","Mitran B","Wegrzyniak O","Lechi F","Cheung P","Nordstrom H","Korsgren O","Frejd FY","Eriksson J","Lofblom J","Bitzios A","Eriksson O","Zhang B"],"additional_accession":[]},"is_claimable":false,"name":"Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule.","description":"Non-invasive assessment of fibrogenic activity, rather than fibrotic scars, could significantly improve the management of fibrotic diseases and the development of anti-fibrotic drugs. This study explores the potential of an Affibody molecule (Z09591) labeled with the Al(18)F-restrained complexing agent (RESCA) method as a tracer for the non-invasive detection of fibrogenic cells. Z09591 was functionalized with the RESCA chelator for direct labeling with [<sup>18</sup>F]AlF. <i>In vivo</i> positron emission tomography/magnetic resonance imaging scans on U-87 tumor-bearing mice exhibited high selectivity of the resulting radiotracer, [<sup>18</sup>F]AlF-RESCA-Z09591, for platelet-derived growth factor receptor β (PDGFRβ), with minimal non-specific background uptake. Evaluation in a mouse mod","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T01:43:44.811Z","creation":"2025-04-06T03:15:49.022Z"},"accession":"S-EPMC11039342","cross_references":{"pubmed":["38660405"],"doi":["10.1016/j.isci.2024.109688"]}}