biostudies-literatureWuestefeld ANICHD NIH HHSNIA NIH HHSWenner-Gren FoundationNational Institutes of HealthAlzheimer's AssociationCanadian Institutes of Health ResearchNational Institute on AgingCIHRHorizon 2020 Framework ProgrammeAlzheimer SocietyMarcus Wallenbergs Stiftelse för Internationellt Vetenskapligt SamarbeteAlzheimer's AssociationNIH HHSBiotechnology and Biological Sciences Research Council241-260https://www.ebi.ac.uk/biostudies/studies/S-EPMC11039382biostudies-literatureUnknown34(5)The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as Alzheimer's disease neurofibrillary tau tangles. The MTL cortex is composed of several subregions which differ in their functional and cytoarchitectonic features. As neuroanatomical schools rely on different cytoarchitectonic definitions of these subregions, it is unclear to what extent their delineations of MTL cortex subregions overlap. Here, we provide an overview of cytoarchitectonic definitions of the entorhinal and parahippocampal cortices as well as Brodmann areas (BA) 35 and 36, as provided by four neuroanatomists from different laboratories, aiming to identify the rationale for overlapping and diverging delineations. NiHippocampusComparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories.PMC11039382P01AG066597F32AG074621BB/V010549/1R01 AG070592R01 AG057672AARFD‐21‐852597F32 HD108960RF1 AG072056945539P30 AG072979F32 AG074621T32 AG0276682020.0004R01‐AG070592F32AG071263RF1 AG069474ESh2020‐002CIHR PJT162292R01AG057672R01 AG056014P30 AG066507R01-AG070592F32 AG071263RF1 AG056014RF1AG072056R01 AG069474P01 AG066597P30AG072979Wisse LEMPuliyadi VDaugherty AMLim STrotman WBerron DIniguez de Onzono Martin MMBedard MLDing SLIttyerah RLopez MMKedo OArtacho-Perula ECanada KLWang LBuendia EAmunts KDalton MAIrwin DJAdams JNDel Mar Arroyo-Jimenez Mde Flores RAugustinack JCLa Joie RDenning AOlsen RKVela ATran TTYushkevich PBaumeister HHodgetts CJChung Ede la Rosa Prieto CDel Pilar Marcos-Rabal MInsausti RSchuck TLee EBMazloum-Farzaghi NBakker AWuestefeld AfalseComparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories.The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as Alzheimer's disease neurofibrillary tau tangles. The MTL cortex is composed of several subregions which differ in their functional and cytoarchitectonic features. As neuroanatomical schools rely on different cytoarchitectonic definitions of these subregions, it is unclear to what extent their delineations of MTL cortex subregions overlap. Here, we provide an overview of cytoarchitectonic definitions of the entorhinal and parahippocampal cortices as well as Brodmann areas (BA) 35 and 36, as provided by four neuroanatomists from different laboratories, aiming to identify the rationale for overlapping and diverging delineations. Ni2024-01-01T00:00:00Z2024 May2025-07-03T03:04:55.856Z2025-07-03T03:04:55.856ZS-EPMC110393823841596210.1002/hipo.23602