{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(5)"],"submitter":["Seo N"],"funding":["Amgen"],"pubmed_abstract":["<h4>Introduction</h4>ABP 938 is being developed as a biosimilar candidate to aflibercept reference product (RP), a biologic used for certain angiogenic eye disorders. This study was designed to provide a comparative analytical assessment of the structural and functional attributes of ABP 938 and aflibercept RP sourced from the United States (US) and the European Union (EU).<h4>Methods</h4>Structural and functional characterization studies were performed using state-of-the-art analytical techniques that were appropriate to assess relevant quality attributes and capable of detecting qualitative and quantitative differences in primary structure, higher-order structure and biophysical properties, product-related substances and impurities, general properties, and biological activities.<h4>Resul"],"journal":["Ophthalmology and therapy"],"pagination":["1303-1320"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11039433"],"repository":["biostudies-literature"],"pubmed_title":["Analytical and Functional Similarity of Aflibercept Biosimilar ABP 938 with Aflibercept Reference Product."],"pmcid":["PMC11039433"],"pubmed_authors":["Matthies K","Ng M","Liu J","Wong HY","Seo N","Chung HSH","Crouse-Zeineddini J","Kuhns S","Kalenian K","Guan X","Padaki R","Wang T","Foltz IN","Cao S","Wikstrom M"],"additional_accession":[]},"is_claimable":false,"name":"Analytical and Functional Similarity of Aflibercept Biosimilar ABP 938 with Aflibercept Reference Product.","description":"<h4>Introduction</h4>ABP 938 is being developed as a biosimilar candidate to aflibercept reference product (RP), a biologic used for certain angiogenic eye disorders. This study was designed to provide a comparative analytical assessment of the structural and functional attributes of ABP 938 and aflibercept RP sourced from the United States (US) and the European Union (EU).<h4>Methods</h4>Structural and functional characterization studies were performed using state-of-the-art analytical techniques that were appropriate to assess relevant quality attributes and capable of detecting qualitative and quantitative differences in primary structure, higher-order structure and biophysical properties, product-related substances and impurities, general properties, and biological activities.<h4>Resul","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-04-22T20:43:24.456Z","creation":"2025-04-06T03:17:41.105Z"},"accession":"S-EPMC11039433","cross_references":{"pubmed":["38507189"],"doi":["10.1007/s40123-024-00914-1"]}}