biostudies-literatureZhou YNational Cancer InstituteNCI NIH HHSKemper and Ethel Marley Foundation9368https://www.ebi.ac.uk/biostudies/studies/S-EPMC11039710biostudies-literatureUnknown14(1)Although colorectal cancer (CRC) remains the second leading cause of cancer-related death in the United States, the overall incidence and mortality from the disease have declined in recent decades. In contrast, there has been a steady increase in the incidence of CRC in individuals under 50 years of age. Hereditary syndromes contribute disproportionately to early onset CRC (EOCRC). These include microsatellite instability high (MSI+) tumors arising in patients with Lynch Syndrome. However, most EOCRCs are not associated with familial syndromes or MSI+ genotypes. Comprehensive genomic profiling has provided the basis of improved more personalized treatments for older CRC patients. However, less is known about the basis of sporadic EOCRC. To define the genomic landscape of EOCRC we used DNA Scientific reportsGenomic landscape of diploid and aneuploid microsatellite stable early onset colorectal cancer.PMC110397105P30 CA15083-36UH3 CA238926UH3CA238926Chen JChen XRamanathan RKKossick KFBoardman LABarrett MTZhou YKendrick CDGraham RPfalseGenomic landscape of diploid and aneuploid microsatellite stable early onset colorectal cancer.Although colorectal cancer (CRC) remains the second leading cause of cancer-related death in the United States, the overall incidence and mortality from the disease have declined in recent decades. In contrast, there has been a steady increase in the incidence of CRC in individuals under 50 years of age. Hereditary syndromes contribute disproportionately to early onset CRC (EOCRC). These include microsatellite instability high (MSI+) tumors arising in patients with Lynch Syndrome. However, most EOCRCs are not associated with familial syndromes or MSI+ genotypes. Comprehensive genomic profiling has provided the basis of improved more personalized treatments for older CRC patients. However, less is known about the basis of sporadic EOCRC. To define the genomic landscape of EOCRC we used DNA 2024-01-01T00:00:00Z2024 Apr2025-04-22T20:40:13.516Z2025-04-06T03:16:39.051ZS-EPMC110397103865404410.1038/s41598-024-59398-5