{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(9)"],"submitter":["Gatica-Garcia B"],"pubmed_abstract":["JOURNAL/nrgr/04.03/01300535-202409000-00039/figure1/v/2024-01-16T170235Z/r/image-tiff Parkinsonism by unilateral, intranigral β-sitosterol β-D-glucoside administration in rats is distinguished in that the α-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time, thus replicating several clinical features of Parkinson's disease, a typical α-synucleinopathy. As Nurr1 represses α-synuclein, we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateral β-sitosterol β-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 post-transfection. This study found that rNurr1-V5 expression but not that of the green fluorescent protein (the neg"],"journal":["Neural regeneration research"],"pagination":["2057-2067"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11040301"],"repository":["biostudies-literature"],"pubmed_title":["Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats with α-synucleinopathy."],"pmcid":["PMC11040301"],"pubmed_authors":["Luna-Herrera C","Mascotte-Cruz JU","Fernandez-Parrilla MA","Martinez-Fong D","Maldonado-Berny M","Gutierrez-Castillo ME","Valenzuela-Arzeta IE","Gatica-Garcia B","Lopez-Salas FE","Santoyo-Salazar J","Rodriguez-Oviedo CP","Reyes-Corona D","Espadas-Alvarez AJ","Bannon MJ","Soto-Rojas LO","Martinez-Davila IA","Escobedo L"],"additional_accession":[]},"is_claimable":false,"name":"Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats with α-synucleinopathy.","description":"JOURNAL/nrgr/04.03/01300535-202409000-00039/figure1/v/2024-01-16T170235Z/r/image-tiff Parkinsonism by unilateral, intranigral β-sitosterol β-D-glucoside administration in rats is distinguished in that the α-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time, thus replicating several clinical features of Parkinson's disease, a typical α-synucleinopathy. As Nurr1 represses α-synuclein, we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateral β-sitosterol β-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 post-transfection. This study found that rNurr1-V5 expression but not that of the green fluorescent protein (the neg","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-04-08T15:29:51.478Z","creation":"2026-04-08T04:48:25.612Z"},"accession":"S-EPMC11040301","cross_references":{"pubmed":["38227536"],"doi":["10.4103/1673-5374.391190"]}}