biostudies-literatureUnknown19(9)Gatica-Garcia BJOURNAL/nrgr/04.03/01300535-202409000-00039/figure1/v/2024-01-16T170235Z/r/image-tiff Parkinsonism by unilateral, intranigral β-sitosterol β-D-glucoside administration in rats is distinguished in that the α-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time, thus replicating several clinical features of Parkinson's disease, a typical α-synucleinopathy. As Nurr1 represses α-synuclein, we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateral β-sitosterol β-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 post-transfection. This study found that rNurr1-V5 expression but not that of the green fluorescent protein (the negNeural regeneration research2057-2067https://www.ebi.ac.uk/biostudies/studies/S-EPMC11040301biostudies-literatureUnilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats with α-synucleinopathy.PMC11040301Luna-Herrera CMascotte-Cruz JUFernandez-Parrilla MAMartinez-Fong DMaldonado-Berny MGutierrez-Castillo MEValenzuela-Arzeta IEGatica-Garcia BLopez-Salas FESantoyo-Salazar JRodriguez-Oviedo CPReyes-Corona DEspadas-Alvarez AJBannon MJSoto-Rojas LOMartinez-Davila IAEscobedo LfalseUnilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats with α-synucleinopathy.JOURNAL/nrgr/04.03/01300535-202409000-00039/figure1/v/2024-01-16T170235Z/r/image-tiff Parkinsonism by unilateral, intranigral β-sitosterol β-D-glucoside administration in rats is distinguished in that the α-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time, thus replicating several clinical features of Parkinson's disease, a typical α-synucleinopathy. As Nurr1 represses α-synuclein, we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateral β-sitosterol β-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 post-transfection. This study found that rNurr1-V5 expression but not that of the green fluorescent protein (the neg2024-01-01T00:00:00Z2024 Sep2026-04-08T15:29:51.478Z2026-04-08T04:48:25.612ZS-EPMC110403013822753610.4103/1673-5374.391190