{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang J"],"funding":["National Multiple Sclerosis Society","National Natural Science Foundation of China"],"pagination":["e202310143"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11040499"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["223(7)"],"pubmed_abstract":["Chromatin-remodeling protein BRG1/SMARCA4 is pivotal for establishing oligodendrocyte (OL) lineage identity. However, its functions for oligodendrocyte-precursor cell (OPC) differentiation within the postnatal brain and during remyelination remain elusive. Here, we demonstrate that Brg1 loss profoundly impairs OPC differentiation in the brain with a comparatively lesser effect in the spinal cord. Moreover, BRG1 is critical for OPC remyelination after injury. Integrative transcriptomic/genomic profiling reveals that BRG1 exhibits a dual role by promoting OPC differentiation networks while repressing OL-inhibitory cues and proneuronal programs. Furthermore, we find that BRG1 interacts with EED/PRC2 polycomb-repressive-complexes to enhance H3K27me3-mediated repression at gene loci associated "],"journal":["The Journal of cell biology"],"pubmed_title":["BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination."],"pmcid":["PMC11040499"],"funding_grant_id":["RG2110","No. 82104181"],"pubmed_authors":["Weng Q","Liu X","Xin M","Yang L","Du Y","Nicholson E","Lu QR","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination.","description":"Chromatin-remodeling protein BRG1/SMARCA4 is pivotal for establishing oligodendrocyte (OL) lineage identity. However, its functions for oligodendrocyte-precursor cell (OPC) differentiation within the postnatal brain and during remyelination remain elusive. Here, we demonstrate that Brg1 loss profoundly impairs OPC differentiation in the brain with a comparatively lesser effect in the spinal cord. Moreover, BRG1 is critical for OPC remyelination after injury. Integrative transcriptomic/genomic profiling reveals that BRG1 exhibits a dual role by promoting OPC differentiation networks while repressing OL-inhibitory cues and proneuronal programs. Furthermore, we find that BRG1 interacts with EED/PRC2 polycomb-repressive-complexes to enhance H3K27me3-mediated repression at gene loci associated ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-07-15T04:58:22.028Z","creation":"2025-04-04T02:21:05.86Z"},"accession":"S-EPMC11040499","cross_references":{"pubmed":["38652118"],"doi":["10.1083/jcb.202310143"]}}