{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(1)"],"submitter":["Fu L"],"pubmed_abstract":["<h4>Background</h4>Epidemiological research and systematic meta-analyses indicate a higher risk of B-cell lymphomas in patients with chronic hepatitis C virus (HCV) compared to non-infected individuals. However, the genetic links between HCV and these lymphomas remain under-researched.<h4>Methods</h4>Mendelian randomization analysis was employed to explore the association between chronic hepatitis C (CHC) and B-cell lymphomas as well as chronic lymphocytic leukemia (CLL). Approximate Bayes Factor (ABF) localization analysis was conducted to find shared genetic variants that might connect CHC with B-cell lymphomas and chronic lymphocytic leukemia (CLL). Furthermore, The Variant Effect Predictor (VEP) was utilized to annotate the functional effects of the identified genetic variants.<h4>Resu"],"journal":["Infectious agents and cancer"],"pagination":["15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11040981"],"repository":["biostudies-literature"],"pubmed_title":["Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma."],"pmcid":["PMC11040981"],"pubmed_authors":["Chen Z","Zhang Z","Fu J","Feng W","Fu L","Yu J","Hong P","Gao F","Jin J"],"additional_accession":[]},"is_claimable":false,"name":"Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma.","description":"<h4>Background</h4>Epidemiological research and systematic meta-analyses indicate a higher risk of B-cell lymphomas in patients with chronic hepatitis C virus (HCV) compared to non-infected individuals. However, the genetic links between HCV and these lymphomas remain under-researched.<h4>Methods</h4>Mendelian randomization analysis was employed to explore the association between chronic hepatitis C (CHC) and B-cell lymphomas as well as chronic lymphocytic leukemia (CLL). Approximate Bayes Factor (ABF) localization analysis was conducted to find shared genetic variants that might connect CHC with B-cell lymphomas and chronic lymphocytic leukemia (CLL). Furthermore, The Variant Effect Predictor (VEP) was utilized to annotate the functional effects of the identified genetic variants.<h4>Resu","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-04-08T18:57:34.696Z","creation":"2026-04-08T11:06:41.078Z"},"accession":"S-EPMC11040981","cross_references":{"pubmed":["38654358"],"doi":["10.1186/s13027-024-00577-4"]}}