biostudies-literatureUnknown19(1)Fu L<h4>Background</h4>Epidemiological research and systematic meta-analyses indicate a higher risk of B-cell lymphomas in patients with chronic hepatitis C virus (HCV) compared to non-infected individuals. However, the genetic links between HCV and these lymphomas remain under-researched.<h4>Methods</h4>Mendelian randomization analysis was employed to explore the association between chronic hepatitis C (CHC) and B-cell lymphomas as well as chronic lymphocytic leukemia (CLL). Approximate Bayes Factor (ABF) localization analysis was conducted to find shared genetic variants that might connect CHC with B-cell lymphomas and chronic lymphocytic leukemia (CLL). Furthermore, The Variant Effect Predictor (VEP) was utilized to annotate the functional effects of the identified genetic variants.<h4>ResuInfectious agents and cancer15https://www.ebi.ac.uk/biostudies/studies/S-EPMC11040981biostudies-literatureShared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma.PMC11040981Chen ZZhang ZFu JFeng WFu LYu JHong PGao FJin JfalseShared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma.<h4>Background</h4>Epidemiological research and systematic meta-analyses indicate a higher risk of B-cell lymphomas in patients with chronic hepatitis C virus (HCV) compared to non-infected individuals. However, the genetic links between HCV and these lymphomas remain under-researched.<h4>Methods</h4>Mendelian randomization analysis was employed to explore the association between chronic hepatitis C (CHC) and B-cell lymphomas as well as chronic lymphocytic leukemia (CLL). Approximate Bayes Factor (ABF) localization analysis was conducted to find shared genetic variants that might connect CHC with B-cell lymphomas and chronic lymphocytic leukemia (CLL). Furthermore, The Variant Effect Predictor (VEP) was utilized to annotate the functional effects of the identified genetic variants.<h4>Resu2024-01-01T00:00:00Z2024 Apr2026-04-08T18:57:34.696Z2026-04-08T11:06:41.078ZS-EPMC110409813865435810.1186/s13027-024-00577-4