{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Fan R"],"pubmed_abstract":["<h4>Background</h4>Human tumors pose significant challenges, with targeted therapy against specific molecular targets or signaling pathways being a mainstay alongside surgical resection. Previous studies have implicated KHDRBS1 in the oncogenesis of certain human tumors such as colorectal and prostate cancers, underscoring its potential as a therapeutic target. However, the comprehensive expression pattern of KHDRBS1 in hepatocellular carcinoma (HCC) warrants further exploration.<h4>Methods</h4>Integrating and analyzing multi-omics, multi-cohort data from public databases, coupled with clinical samples and molecular biology validation, we elucidate the oncogenic role of KHDRBS1 in HCC progression. Additionally, leveraging HCC single-cell sequencing data, we segregate malignant cells into K"],"journal":["Frontiers in immunology"],"pagination":["1393801"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11041018"],"repository":["biostudies-literature"],"pubmed_title":["KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity."],"pmcid":["PMC11041018"],"pubmed_authors":["Gong Q","Tang S","Shen D","Liu D","Fan R","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity.","description":"<h4>Background</h4>Human tumors pose significant challenges, with targeted therapy against specific molecular targets or signaling pathways being a mainstay alongside surgical resection. Previous studies have implicated KHDRBS1 in the oncogenesis of certain human tumors such as colorectal and prostate cancers, underscoring its potential as a therapeutic target. However, the comprehensive expression pattern of KHDRBS1 in hepatocellular carcinoma (HCC) warrants further exploration.<h4>Methods</h4>Integrating and analyzing multi-omics, multi-cohort data from public databases, coupled with clinical samples and molecular biology validation, we elucidate the oncogenic role of KHDRBS1 in HCC progression. Additionally, leveraging HCC single-cell sequencing data, we segregate malignant cells into K","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-22T20:46:18.194Z","creation":"2025-04-06T03:16:14.751Z"},"accession":"S-EPMC11041018","cross_references":{"pubmed":["38660302"],"doi":["10.3389/fimmu.2024.1393801"]}}