{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gaba A"],"funding":["Alzheimer’s Association Clinician Scientist Fellowship","BrightFocus Foundation Alzheimer’s Disease Research Program","Alzheimer’s Association Research Fellowship","National Institutes of Health"],"pagination":["igae029"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11041407"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(5)"],"pubmed_abstract":["<h4>Background and objectives</h4>Delirium and depression are prevalent in aging. There is considerable clinical overlap, including shared symptoms and comorbid conditions, including Alzheimer's disease, functional decline, and mortality. Despite this, the long-term relationship between depression and delirium remains unclear. This study assessed the associations of depression symptom burden and its trajectory with delirium risk in a 12-year prospective study of older hospitalized individuals.<h4>Research design and methods</h4>A total of 319 141 UK Biobank participants between 2006 and 2010 (mean age 58 years [range 37-74, <i>SD</i> = 8], 54% women) reported frequency (0-3) of 4 depressive symptoms (mood, disinterest, tenseness, or lethargy) in the preceding 2 weeks prior to initial asses"],"journal":["Innovation in aging"],"pubmed_title":["Associations Between Depression Symptom Burden and Delirium Risk: A Prospective Cohort Study."],"pmcid":["PMC11041407"],"funding_grant_id":["AACSF-23-1148490","AARFD-22-928372","R01AG083799","RF1AG064312","R03AG067985","A2020886S"],"pubmed_authors":["Cai R","Zheng X","Gaba A","Gao L","Li P","Hu K","Gao C"],"additional_accession":[]},"is_claimable":false,"name":"Associations Between Depression Symptom Burden and Delirium Risk: A Prospective Cohort Study.","description":"<h4>Background and objectives</h4>Delirium and depression are prevalent in aging. There is considerable clinical overlap, including shared symptoms and comorbid conditions, including Alzheimer's disease, functional decline, and mortality. Despite this, the long-term relationship between depression and delirium remains unclear. This study assessed the associations of depression symptom burden and its trajectory with delirium risk in a 12-year prospective study of older hospitalized individuals.<h4>Research design and methods</h4>A total of 319 141 UK Biobank participants between 2006 and 2010 (mean age 58 years [range 37-74, <i>SD</i> = 8], 54% women) reported frequency (0-3) of 4 depressive symptoms (mood, disinterest, tenseness, or lethargy) in the preceding 2 weeks prior to initial asses","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-22T20:44:12.062Z","creation":"2025-04-06T03:17:28.845Z"},"accession":"S-EPMC11041407","cross_references":{"pubmed":["38660114"],"doi":["10.1093/geroni/igae029"]}}