biostudies-literatureGaba AAlzheimer’s Association Clinician Scientist FellowshipBrightFocus Foundation Alzheimer’s Disease Research ProgramAlzheimer’s Association Research FellowshipNational Institutes of Healthigae029https://www.ebi.ac.uk/biostudies/studies/S-EPMC11041407biostudies-literatureUnknown8(5)<h4>Background and objectives</h4>Delirium and depression are prevalent in aging. There is considerable clinical overlap, including shared symptoms and comorbid conditions, including Alzheimer's disease, functional decline, and mortality. Despite this, the long-term relationship between depression and delirium remains unclear. This study assessed the associations of depression symptom burden and its trajectory with delirium risk in a 12-year prospective study of older hospitalized individuals.<h4>Research design and methods</h4>A total of 319 141 UK Biobank participants between 2006 and 2010 (mean age 58 years [range 37-74, <i>SD</i> = 8], 54% women) reported frequency (0-3) of 4 depressive symptoms (mood, disinterest, tenseness, or lethargy) in the preceding 2 weeks prior to initial assesInnovation in agingAssociations Between Depression Symptom Burden and Delirium Risk: A Prospective Cohort Study.PMC11041407AACSF-23-1148490AARFD-22-928372R01AG083799RF1AG064312R03AG067985A2020886SCai RZheng XGaba AGao LLi PHu KGao CfalseAssociations Between Depression Symptom Burden and Delirium Risk: A Prospective Cohort Study.<h4>Background and objectives</h4>Delirium and depression are prevalent in aging. There is considerable clinical overlap, including shared symptoms and comorbid conditions, including Alzheimer's disease, functional decline, and mortality. Despite this, the long-term relationship between depression and delirium remains unclear. This study assessed the associations of depression symptom burden and its trajectory with delirium risk in a 12-year prospective study of older hospitalized individuals.<h4>Research design and methods</h4>A total of 319 141 UK Biobank participants between 2006 and 2010 (mean age 58 years [range 37-74, <i>SD</i> = 8], 54% women) reported frequency (0-3) of 4 depressive symptoms (mood, disinterest, tenseness, or lethargy) in the preceding 2 weeks prior to initial asses2024-01-01T00:00:00Z20242025-04-22T20:44:12.062Z2025-04-06T03:17:28.845ZS-EPMC110414073866011410.1093/geroni/igae029