{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schevenels G"],"funding":["European Research Council"],"pagination":["863-871"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11041701"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["628(8009)"],"pubmed_abstract":["Vertebrate organs require locally adapted blood vessels<sup>1,2</sup>. The gain of such organotypic vessel specializations is often deemed to be molecularly unrelated to the process of organ vascularization. Here, opposing this model, we reveal a molecular mechanism for brain-specific angiogenesis that operates under the control of Wnt7a/b ligands-well-known blood-brain barrier maturation signals<sup>3-5</sup>. The control mechanism relies on Wnt7a/b-dependent expression of Mmp25, which we find is enriched in brain endothelial cells. CRISPR-Cas9 mutagenesis in zebrafish reveals that this poorly characterized glycosylphosphatidylinositol-anchored matrix metalloproteinase is selectively required in endothelial tip cells to enable their initial migration across the pial basement membrane lini"],"journal":["Nature"],"pubmed_title":["A brain-specific angiogenic mechanism enabled by tip cell specialization."],"pmcid":["PMC11041701"],"funding_grant_id":["865176"],"pubmed_authors":["Dieu M","Vandenborne A","De Grande L","Vermeersch M","Vanlandewijck M","He L","Christou B","America M","Guenther S","Germano RFV","Vanhollebeke B","Schevenels G","Perez-Morga D","Martin M","Cabochette P","Renard P","Betsholtz C"],"additional_accession":[]},"is_claimable":false,"name":"A brain-specific angiogenic mechanism enabled by tip cell specialization.","description":"Vertebrate organs require locally adapted blood vessels<sup>1,2</sup>. The gain of such organotypic vessel specializations is often deemed to be molecularly unrelated to the process of organ vascularization. Here, opposing this model, we reveal a molecular mechanism for brain-specific angiogenesis that operates under the control of Wnt7a/b ligands-well-known blood-brain barrier maturation signals<sup>3-5</sup>. The control mechanism relies on Wnt7a/b-dependent expression of Mmp25, which we find is enriched in brain endothelial cells. CRISPR-Cas9 mutagenesis in zebrafish reveals that this poorly characterized glycosylphosphatidylinositol-anchored matrix metalloproteinase is selectively required in endothelial tip cells to enable their initial migration across the pial basement membrane lini","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-01T21:54:22.166Z","creation":"2025-04-06T03:15:37.637Z"},"accession":"S-EPMC11041701","cross_references":{"pubmed":["38570687"],"doi":["10.1038/s41586-024-07283-6"]}}