{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Depuydt MAC"],"funding":["Dutch Research Council (NWO)","ZonMw"],"pagination":["112-125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11041750"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(2)"],"pubmed_abstract":["Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell samples to assess the extent of TCR clonality and antigen-specific activation within the various T cell subsets. We observed the highest degree of plaque-specific clonal expansion in effector CD4<sup>+</sup> T cells, and these clonally expanded T cells expressed genes such as <i>CD69</i>, <i>FOS</i> and <i>FOSB</i>, indicative of recent TCR engagement, suggesting antigen-specific stimulation. CellChat analysis suggested multiple potential interactions of these effector CD4<sup>+</sup> T cells with"],"journal":["Nature cardiovascular research"],"pubmed_title":["Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells."],"pmcid":["PMC11041750"],"funding_grant_id":["VI.Veni.212.196","09120011910025","95105013"],"pubmed_authors":["Hemme E","Peeters JAHM","de Mol J","Bot I","Bernabe Kleijn MNA","Foks AC","Slutter B","Delfos L","Wezel A","de Borst GJ","de Winther MPJ","Depuydt MAC","Schaftenaar FH","Prange KHM","de Jong MJM","Pasterkamp G","Boltjes A","Goncalves L","Smeets HJ","Kuiper J"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells.","description":"Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell samples to assess the extent of TCR clonality and antigen-specific activation within the various T cell subsets. We observed the highest degree of plaque-specific clonal expansion in effector CD4<sup>+</sup> T cells, and these clonally expanded T cells expressed genes such as <i>CD69</i>, <i>FOS</i> and <i>FOSB</i>, indicative of recent TCR engagement, suggesting antigen-specific stimulation. CellChat analysis suggested multiple potential interactions of these effector CD4<sup>+</sup> T cells with","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-06-01T09:16:20.322Z","creation":"2026-04-08T11:04:28.855Z"},"accession":"S-EPMC11041750","cross_references":{"pubmed":["38665903"],"doi":["10.1038/s44161-022-00208-4"]}}