{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Melinyte-Ankudavice K"],"pubmed_abstract":["<h4>Background</h4>Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring.<h4>Objective</h4>We sought to assess the association between cardiac-related genes and whole-heart myocardial mechanics or morphometrics in nonischemic dilated cardiomyopathy (NIDCM).<h4>Methods</h4>It was a prospective study consisting of patients with NIDCM. All patients were referred for genetic testing and a genetic analysis was performed using Illumina NextSeq 550 and a commercial gene capture panel of 233 genes (Systems Genomics, Cardiac-GeneSGKit®). It was analyzed whether there are significant differences in clinical, two-dimensional (2D) echocardiographic, and magnetic resonance ima"],"journal":["BMC cardiovascular disorders"],"pagination":["224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11044472"],"repository":["biostudies-literature"],"pubmed_title":["Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy."],"pmcid":["PMC11044472"],"pubmed_authors":["Melinyte-Ankudavice K","Krikstolaitis R","Galnaitiene G","Mizariene V","Sukys M","Sakalyte G","Jurkevicius R","Ereminiene E","Krilavicius T","Kasputyte G"],"additional_accession":[]},"is_claimable":false,"name":"Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy.","description":"<h4>Background</h4>Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring.<h4>Objective</h4>We sought to assess the association between cardiac-related genes and whole-heart myocardial mechanics or morphometrics in nonischemic dilated cardiomyopathy (NIDCM).<h4>Methods</h4>It was a prospective study consisting of patients with NIDCM. All patients were referred for genetic testing and a genetic analysis was performed using Illumina NextSeq 550 and a commercial gene capture panel of 233 genes (Systems Genomics, Cardiac-GeneSGKit®). It was analyzed whether there are significant differences in clinical, two-dimensional (2D) echocardiographic, and magnetic resonance ima","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-02T02:13:20.95Z","creation":"2026-04-13T03:12:44.401Z"},"accession":"S-EPMC11044472","cross_references":{"pubmed":["38664609"],"doi":["10.1186/s12872-024-03888-x"]}}