biostudies-literatureUnknown24(1)Melinyte-Ankudavice K<h4>Background</h4>Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring.<h4>Objective</h4>We sought to assess the association between cardiac-related genes and whole-heart myocardial mechanics or morphometrics in nonischemic dilated cardiomyopathy (NIDCM).<h4>Methods</h4>It was a prospective study consisting of patients with NIDCM. All patients were referred for genetic testing and a genetic analysis was performed using Illumina NextSeq 550 and a commercial gene capture panel of 233 genes (Systems Genomics, Cardiac-GeneSGKit®). It was analyzed whether there are significant differences in clinical, two-dimensional (2D) echocardiographic, and magnetic resonance imaBMC cardiovascular disorders224https://www.ebi.ac.uk/biostudies/studies/S-EPMC11044472biostudies-literatureAssociation of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy.PMC11044472Melinyte-Ankudavice KKrikstolaitis RGalnaitiene GMizariene VSukys MSakalyte GJurkevicius REreminiene EKrilavicius TKasputyte GfalseAssociation of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy.<h4>Background</h4>Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring.<h4>Objective</h4>We sought to assess the association between cardiac-related genes and whole-heart myocardial mechanics or morphometrics in nonischemic dilated cardiomyopathy (NIDCM).<h4>Methods</h4>It was a prospective study consisting of patients with NIDCM. All patients were referred for genetic testing and a genetic analysis was performed using Illumina NextSeq 550 and a commercial gene capture panel of 233 genes (Systems Genomics, Cardiac-GeneSGKit®). It was analyzed whether there are significant differences in clinical, two-dimensional (2D) echocardiographic, and magnetic resonance ima2024-01-01T00:00:00Z2024 Apr2026-06-02T02:13:20.95Z2026-04-13T03:12:44.401ZS-EPMC110444723866460910.1186/s12872-024-03888-x