{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bilinsky LM"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","U.S. Food and Drug Administration"],"pagination":["100299"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11044893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29"],"pubmed_abstract":["This paper presents an ordinary differential equation (ODE) model of endogenous H<sub>2</sub>O<sub>2</sub> production and elimination in hepatocytes that is unique, at the time of writing, in its ability to accurately compute intracellular H<sub>2</sub>O<sub>2</sub> concentration during incidents of oxidative stress and in its usefulness for constructing PBPK/PD models for ROS-generating xenobiotics. Versions of the model are presented for rat hepatocytes <i>in vitro</i> and mouse liver <i>in vivo</i>. A generic method is given for using the model to create PBPK/PD models which predict intracellular H<sub>2</sub>O<sub>2</sub> concentration and oxidative-stress-induced hepatocyte death; these are identifiable from <i>in vitro</i> data sets reporting cell mortality following xenobiotic expos"],"journal":["Computational toxicology (Amsterdam, Netherlands)"],"pubmed_title":["A Computational Model of Endogenous Hydrogen Peroxide Metabolism in Hepatocytes, Featuring a Critical Role for GSH."],"pmcid":["PMC11044893"],"funding_grant_id":["12013","Y01 S12013001","FDA IAG #224-17-0502"],"pubmed_authors":["Bilinsky LM"],"additional_accession":[]},"is_claimable":false,"name":"A Computational Model of Endogenous Hydrogen Peroxide Metabolism in Hepatocytes, Featuring a Critical Role for GSH.","description":"This paper presents an ordinary differential equation (ODE) model of endogenous H<sub>2</sub>O<sub>2</sub> production and elimination in hepatocytes that is unique, at the time of writing, in its ability to accurately compute intracellular H<sub>2</sub>O<sub>2</sub> concentration during incidents of oxidative stress and in its usefulness for constructing PBPK/PD models for ROS-generating xenobiotics. Versions of the model are presented for rat hepatocytes <i>in vitro</i> and mouse liver <i>in vivo</i>. A generic method is given for using the model to create PBPK/PD models which predict intracellular H<sub>2</sub>O<sub>2</sub> concentration and oxidative-stress-induced hepatocyte death; these are identifiable from <i>in vitro</i> data sets reporting cell mortality following xenobiotic expos","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T02:46:45.219Z","creation":"2025-04-04T02:46:45.219Z"},"accession":"S-EPMC11044893","cross_references":{"pubmed":["38682127"],"doi":["10.1016/j.comtox.2024.100299"]}}